Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 6 of 6 for “"SMAC mimetics"”.
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SMAC Mimetics Sensitize HIV-Infected Cells to MG1-Mediated Death
… mitochondria derived activator of caspases (SMAC) mimetic (AEG 40730, LCL-161, birinapant) to kill the latently HIV-infected lymphocytic cell line J1.1 and myelocytic cell line OM10.1. In HIV-infected cell lines, it was shown that the order of administration of MG1 and SMAC mimetics is …
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Overcoming Acquired Resistance to BRAF Inhibitors by Novel Synergistic Drug Combination and Discovery of Novel Smac Mimetics as Selective Survivin Inhibitors
… mitochondria-derived activator of caspases (Smac) is a rational strategy to design potential IAP inhibitors. In this report, we used the bioactive conformation of AVPI tetrapeptide in the N-terminus of Smac as a template and performed a shape-based virtual screening against a drug-like …
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Prognostic biomarkers for head and neck squamous carcinoma
… therapeutics for this disease. TRAIL and Smac mimetics are novel promising anticancer agents. However, their effect on head and neck cancers so far has not been tested. The main objective of this research was to investigate biomarkers which could predict response of head and neck squamous …
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Loss of Caspase-8 Function In Combination With Smac Mimetic Treatment Sensitizes Head and Neck Squamous Carcinoma to Radiation Through Induction of Necroptosis.
… mitochondria-derived activator of caspase (SMAC) mimetic, Birinapant, when combined with pan-caspase inhibitors zVAD-FMK or emricasan. Strikingly, inhibition of CASP8 function via knockdown or emricasan treatment was associated with enhanced radiation killing by Birinapant through induction …
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Type I Interferon-Mediated Killing of Cancer Cells with IAP-Targeted Combination Immunotherapy
SMAC mimetic compounds (SMCs) are small molecule antagonists of the Inhibitor of Apoptosis (IAP) family of proteins. Binding of SMCs to the IAPs results in the sensitization of cancer cells to apoptosis in the presence of death ligands, such as tumour necrosis factor alpha (TNFα). I hypothesize …
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Roles of protein kinase C in cell death and breast cancer
… several breast cancer cells. Here we show that Smac, a proapoptotic protein, associates with PKCδ in many different cancer cell lines. Furthermore, the PKCδ-Smac association was dissociated upon paclitaxel treatment. Upon PKC activation with TPA the PKCδ-Smac complex was stabilized and the …