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Showing 1 to 8 of 8 for “"SLX4"”.

  1. Analysis of the composition and regulation of the SLX4 complex

    Satriano, LetiziaUniversity of Dundee2014

    dundee Repository record

  2. Characterisation of human SLX4/FANCP, a coordinator of DNA repair nucleases

    Hain, Karolina OttiliaUniversity of Dundee2012

    dundee Repository record

  3. Regulation of structure-selective nucleases by the SLX4 scaffold in ICL repair and HJ resolution

    Nair, NidhiUniversity of Dundee2014

    Mammalian SLX4 is a scaffold protein that directs the formation of a multi-protein DNA processing toolkit that includes three different structure-selective endonucleases: XPF-ERCC1, MUS81-EME1 and SLX1. The SLX4 complex has been shown to have essential roles in repair of DNA interstrand crosslinks …

    dundee Repository record

  4. Transcriptome Analysis of Sea Lamprey Embryogenesis

    Yermolenko, Zakary Ilya2014

    … (signal transducer), PCNA (DNA replication), SLX4 (endonuclease), and PXN (focal adhesion) were selected for their NGS expression levels, GO annotations, and biological function significance. Their NGS expression levels were verified using Real-Time PCR (qPCR). TGFBR1 was up-regulated in the …

    shu-thes Repository record

  5. Identification of low-penetrance alleles, genetic modifiers and mutation analysis in familial breast cancer cases

    Catucci, IreneThe Open University2013

    … Fanconi Anemia (FA) genes <i>PALB2</i> and <i>SLX4</i> as breast cancer predisposing loci. In the <i>PALB2</i> screening, I observed a frequency of deleterious mutation of 2.1 % in familial cases recruited in cancer centers in Milan. Interestingly, I also identified the recurrent mutation …

    the-open-u Repository record

  6. THE DNA DAMAGE CHECKPOINT REGULATES MISMATCH REPAIR COMPLEXES DURING SINGLE STRAND ANNEALING PATHWAY

    VIETRI, MARIA YLENIAUniversità degli Studi di Milano2023

    … endonuclease complex together with Saw1 and Slx4. Furthermore, Slx4 with Rtt107 limits the binding of the DDC mediator Rad9/53BP1 in proximity of the DSB, reducing checkpoint signalling. We observed that the deletion of RAD9 gene rescues the defects in SSA of both rad1Δ and slx4Δ mutant …

    milano Repository record

  7. Fanconi Anaemia DNA crosslink repair factors protect against LINE-1 retrotransposition during mammalian development

    Bona, NazarenoUniversity of Cambridge2022

    … the recombinant FA ICL repair incision complex (SLX4-XPF-ERCC1), I show that it can cleave intermediates of retrotransposition, aborting new integrations. I show that all stages of FA ICL repair, defective in the human disease FA, are required to prevent retrotransposition in vivo. I find that FA …

    cambridge Repository record

  8. Mechanistic Understanding of the Role of TRF1 in Telomere Replication

    Yang, Zhe

    … break (DSB) formation, in this case by the SLX4/SLX1 nuclease. The DSBs are repaired by POLD3/POLD4-dependent break-induced replication (BIR), resulting in fragile telomeres containing conservatively replicated DNA. BIR also promotes fragile telomere formation in cells with FokI-induced …

    rockefeller Repository record