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Showing 1 to 6 of 6 for “"SLP-76"”.

  1. 免疫シグナルアダプター分子SLP-76の複合体形成と機能：1分子追跡による解明

    吉田, 謙太京都大学 (Kyoto University)2015

    kyoto Repository record

  2. Comparison of CLEC-2 and GPVI signaling in platelets: the role of adaptor proteins

    Hughes, Craig EdwardUniversity of Birmingham2010

    … rather than an absolute dependence on adapter SLP-76 for activation of PLC\(_y\)2. The aim of this thesis is to understand some of the key differences in these signalling pathways. GPVI is in complex with FcRwhich contains the ITAM sequence (Yxx(L/I)x\(_{6-12}\)Yxx(L/I)). These two tyrosines …

    birmingham Repository record

  3. Signal Regulation By Cd38, Lyn, And Mapk-Associated Molecules During All-Trans Retinoic Acid-Induced Differentiation Of Acute Myelogenous Leukemia Cells

    Congleton, JohannaCornell University2012

    … CD38 interaction partners. These included SLP-76, Vav1, and Lyn, and we found that this complex was interrupted by inhibiting Lyn. Lyn inhibition also blocked ATRA- and CD38-stimulated phosphorylation of c-Cbl and p85 PI3K, suggesting some aspects of CD38 signaling are dependent on Lyn …

    cornell Repository record

  4. Roles of coagulation factor XIII in the functions of blood platelets

    Magwenzi, Simbarashe G.Hull York Medical School, the University of Hull and the University of York2011

    … of several proteins including Syk, SLP-76 and PLCv2 but not LAT, in adherent platelets. FXIIIa immobilised rapidly on collagen, and enhanced collagen-induced thrombus formation at a shear rate of 800s"1 . When co-immobilised with fibrinogen and vWF, the coagulation factor also …

    hull Repository record

  5. Regulation of Protein Kinases (Syk and PKC zeta) in platelets

    Mayanglambam, AzadTemple University. Libraries2010

    … tyrosine 145 on intracellular adaptor molecule SLP-76 were not significantly affected. Furthermore, the inhibitory action of curcumin on the catalytic activity of Syk was independent of any of its effects on the thromboxane generation because all our studies were performed using aspirin-treated …

    temple Repository record

  6. Die Hämatopoetische Progenitor Kinase (HPK) 1 und NFAT-Transkriptionsfaktoren unterstützen die Apoptose von T-Lymphozyten

    Schulze-Lührmann, JanUniversität Würzburg

    … Nck, Crk, Gads, Grb2, Grap, CrkL sowie SLP-76 gezeigt. Für die Aktivierung der nach TZR-Stimulation in den Lipid-Rafts lokalisierten HPK1 sind sowohl Lck als auch ZAP-70 notwendig [Liou et al., 2000; Liu et al., 2000a; Ling et al., 2001]. Diese Daten legen eine mögliche Funktion von HPK1 …

    wurz-thes Repository record