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Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 20 for “"SLN"”.
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Development of solid lipid nanoparticles for sustained release of anticancer agents
… brief introduction to solid lipid nanoparticles (SLN) is provided and the reasoning behind the use of SLN over other colloidal carriers, such as emulsions and liposomes, are discussed. SLN has many advantageous such as controlled drug release, non-biotoxicity of the carrier, increased …
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The use of lymphoscintigraphy to localise the sentinel lymph node
Sentinel lymph node (SLN) biopsy is being used increasingly for staging early breast carcinoma in place of complete axillary lymph node dissection. The optimal method to identify the SLN and has not been clearly elucidated in the literature. A number of techniques have been proposed for identifying …
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Completion Lymph Node Dissection or Observation for Melanoma Sentinel Lymph Node Metastases: A Decision Analysis
… melanoma patients with sentinel lymph node (SLN) metastases should undergo completion lymph node dissection (CLND). Background: Randomized trial results comparing CLND with observation for patients with SLN metastases are not available. Methods: We developed a Markov model to simulate the …
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Experience using a small field of view gamma camera for intraoperative sentinel lymph node procedures
… the management of cancer. Sentinel lymph node (SLN) biopsy is one method used in the assessment of cancer spread. SLN procedures are standard practice in the management of some cancers although; these procedures have only recently been developed and refined. SLN procedures are commonly used in …
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FUTURE MARITIME SECURITY CONCERNS OF THE SRI LANKA NAVY: CHALLENGES VERSUS SOLUTIONS
This thesis explores how the Sri Lanka Navy (SLN) can effectively face its maritime security challenges by utilizing available resources and establishing a maritime strategy to ensure peace and stability in the Indian Ocean Region (IOR). Specifically, the analysis examines security concerns in the …
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Hot-melt extrusion: A versatile pharmaceutical technology
… for the production of solid lipid nanoparticles (SLN) as drug-carrier systems via hot-melt extrusion (HME) using Quality by Design (QbD) principles. Fenofibrate SLN were prepared by combining two processes: HME technology for melt-emulsification and high-pressure homogenization (HPH) for size …
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Exploring and Contextualising Expertise in Relation to the Safeguard Lead Nurse
… developing the role of the Safeguard Lead Nurse (SLN) as an expert practitioner; a role that developed as a result of increased adult abuse. Methodology: A phenomenological approach using semi-structured interviews was used to explore purposively selected informants’ current practice as an SLN. …
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Analysis of clinical and pathological outcomes of sentinel lymph node biopsy in the SNAC Trial.
Sentinel Lymph Node Biopsy (SLNB) has become the standard procedure to assess the status of the lymphatic drainage in early stages of breast cancer. Currently, SLNB has replaced Complete Axillary Dissection (CAD) when the lymph nodes are clinically negative. The detection of a Sentinel Lymph Node …
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Lipid Nanoparticles as Tools for the Administration of Active Natural Products Aimed to the Treatment of Nervous System Disorders
… of innovative and efficient stealth carriers (sSLN) loaded with these antioxidants, capable of avoiding the defense line represented by the macrophages and improving the drug stability, in order to achieve good bioavailability in the brain. The best strategies to realize sSLN, suitable for …
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RGD-targeted Solid Lipid Nanoparticles Containing Asiatic Acid for the Treatment of Cancer
… into RGD-containing solid lipid nanoparticles (SLNs) after optimisation of the SLN preparation comprised of glyceryl monostearate, glyceryl distearate and glyceryl tristearate lipids and subsequent characterisation on their physicochemical properties. The targeting ability of these AA-containing …
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Novel Plasmonic Nanostructures for Applications in Sensing, Imaging, and Controlled Release
… tracers for noninvasive sentinel lymph node: SLN) imaging by photoacoustic: PA) tomography. The transport kinetics of Au nanocages in a lymphatic system was evaluated by PA imaging on the axillary region of a rat. Several experimental parameters, including the injection concentration, particle …
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Lipid Based Frameworks And Topical Ocular Inserts For The Delivery Of Small Molecule Therapeutics To The Posterior Segment Of The Eye
… was developed into solid lipid nanoparticles (SLNs) and Nanostructured lipid carriers (NLCs). Effect of surface functionalization using chitosan (CS) on lipid nanocarriers was tested to evaluate corneal penetration. Surface modification of SLNs with CS increased ocular penetration of IN. NLCs …
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Langlands Duality in the Generic Fibres of Classical Hitchin Fibrations
… the self-duality in GLn, and duality between SLn and PGLn: Chapter 5 computes the generic bres for Sp2n and SO2n+1 and demonstrates the Langlands duality in the generic bres. Chapter 6 computes the generic bres for SO2n and demonstrates the self-duality. In the SO2n+1 and SO2n cases, generic …
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USE OF NEAR-INFRARED FLUORESCENCE WITH INDOCYANINE GREEN IN SMALL ANIMAL SURGICAL ONCOLOGY AND IN CADAVERIC ANATOMICAL STUDY
… 1. the use of NIRF-ICG for sentinel lymph node (SLN) identification and removal 2. the application of real-time tumor fluorescence-guided surgery (TFGS) for intraoperative decision-making regarding surgical margins 3. the use of NIRF-ICG lymphography in cadavers to support anatomical studies. In …
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Biopharmaceutical approaches for improved drug delivery across ocular barriers
… (cyclodextrins and solid lipid nanoparticles (SLNs)) were evaluated in terms of their ability to improve the ocular bioavailability of hydrophilic and lipophilic compounds, respectively. A novel approach, localized modulation of RPE P-gp using topically co-administered P-gp inhibitors, was …
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INSIGHTS ON THE CROSSTALK BETWEEN THE IMMUNE SYSTEMAND CANCER: IMMUNE CHECKPOINT MOLECULES AND LYMPHOIDPOPULATIONS ASSESSMENT IN CANINE ROUND CELL TUMORS
… in peripheral blood and sentinel lymph nodes (SLNs) of dogs with mast cell tumors (MCTs). Regarding PD-L1, the project evaluated the expression of the surface membrane protein (mPD-L1) by means of flow cytometry (FC), mRNA by real-time qPCR, and soluble protein (sPD-L1) plasmatic concentrations …
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Λεμφαδενική μετάσταση σε luminal-A καρκίνο μαστού: συσχέτιση με βιοδείκτες και ο ρόλος τους ως προγνωστικοί παράγοντες
… MVD ή LVD ως προγνωστικών δεικτών της διήθησης SLN στον καρκίνο του μαστού.
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Circulating tumour DNA: A non-invasive biomarker for melanoma
… imaging techniques and sentinel lymph node (SLN) biopsies (SLNB) are currently the methods employed to stage primary melanomas and detect metastases. Positron emission tomography (PET) with a labelled glucose analogue fluorine 18 fluorodeoxyglucose (18F-FDG) combined with computed tomography …
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Progettazione e studi preformulativi di formulazioni nanotecnologiche per la somministrazione intranasale di composti neuroattivi
… polimeriche (NPs), NPs lipidiche solide (SLN), vettori lipidici nanostrutturati (NLC), NPs inorganiche, NPs proteiche virus-simili e auto-assemblanti (VLNP), dendrimeri, punti quantici (QDs), nanogel, nanoemulsioni (NEs) e liposomi. Nel lavoro II (Corsaro, Lombardo et al. - Applied …