Global ETD Search
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Showing 1 to 3 of 3 for “"SLIT2"”.
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Role of Slit2 in Reducing Complications after Surgical Brain Injury
… <p>In this project we have identified Slit2, an extracellular matrix protein expressed endogenously in the brain, as a potential therapeutic target for reducing SBI-induced complications. Our central hypothesis was that Slit2 will increase after SBI as an endogenous protective …
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Balancing growth and repulsion: Slit proteolysis generates diverse signals in axon guidance
… in vertebrates. The vertebrate homolog of Slit, SLIT2, is proteolytically processed and has similar function in CNS midline repulsion. SLIT2 also acts as a repellent for sensory neurons from dorsal root ganglia (DRG) that infiltrate the spinal cord and branch to grow longitudinally. DRGs cultured …
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The Role of Slit/Robo Signalling in Peripheral Nerve Regeneration
… the nerve bridge expressed Robo1 strongly. The Slit2, Slit3 and Robo1 single adult mutants show normal sciatic nerve morphology, but Slit3 and Robo1 single and double mutants had severely disrupted axon trajectories following sciatic nerve transection. However, Robo1 mutants did not have any …