Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 4 of 4 for “"SLC6A8"”.
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Extracellular Metabolic Energetics Can Promote Cancer Progression
… identified the membrane transporter SLC6a8 as an important effector of the CKB pathway and also a promoter of colon cancer metastasis. The final part of this study reveals miR-483-5p, miR-551a, CKB and SLC6a8 to be clinically relevant across multiple patient datasets and archival …
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Role of the oviduct environment in sperm storage
… and localize the creatine transport channel SLC6A8. We performed SDS-PAGE and immunoblotting to detect SLC6A8 in sperm protein lysates and determined that it is present. To further characterize the distribution of SLC6A8 in sperm, we used immunofluorescence. Our findings demonstrated that the …
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Development of A Gene Therapy for Creatine Transporter Deficiency
… by loss of function mutations in the X-linked SLC6A8 gene. In the absence of creatine transporter cells are unable to uptake creatine, resulting in a depletion of creatine in multiple tissues, including the brain. Symptoms include intellectual disability, developmental delays, hyperactivity, …
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The Role of Adipocytes in the Tumor Microenvironment in Obesity-Driven Breast Cancer Progression
… that knocking down the creatine transporter (Slc6a8) in breast cancer cells fully attenuates obesitydriven tumor progression. These data support a central role for creatine metabolism in breast tumor progression in mice and suggest that adipocyte-derived creatine is utilized by the tumor to …