Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 8 of 8 for “"SLC6A4"”.
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The serotonin transporter gene (SLC6A4) shows differential regulation between children with ASD and typically developing children in a South African population
… expression of the serotonin transporter gene (SLC6A4) is linked to particular ASD traits. This study focuses on a length polymorphic repeat region (5-HTTLPR) upstream of the SLC6A4 promoter, and SLC6A4 promoter DNA methylation. The short variant of 5-HTTLPR is directly linked to lowered SLC6A4 …
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Bridging the link between trauma, brain development and depression: epigenetic mechanisms
… and methylation at the serotonin transporter (SLC6A4) and FK506 binding protein gene (FKBP5) genes (two genes strongly linked to stress regulation and depression). Second, how does childhood trauma, which is known to increase risk for depression, affect (2a) brain development and (2b) SLC6A4 …
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Influence of serotonin-related genes on behavior and body weight
… in the gene encoding the serotonin transporter, SLC6A4, were found. 3) Both the 5-HTTLPR polymorphism and a variable number of tandem repeats (VNTR) in intron 2 (STin2) of SLC6A4 were shown to be associated with binding capacity of the serotonin transporter in brains of suicide attempters. 4) …
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The Molecular Evolution of the Serotonin System in Macaques (MACACA): a Detailed Survey of Four Serotonin-Related Genes
… and behavior: HTR1A, HTR1B, TPH2, and SLC6A4. I examine the pattern of genetic variation within and between several species of macaque, and, using an approach based on molecular evolutionary theory, discern which evolutionary force – positive selection, balancing selection, purifying …
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Serotonergic Circuits Mediating Stress Potentiation of Addiction Risk
… We found that conditional deletion of KOR from Slc6a4 (SERT)-expressing neurons blocked stress-induced potentiation of cocaine conditioned place preference (CPP). Within the dorsal raphe nucleus (DRN), two overlapping populations of KOR-expressing neurons: Slc17a8 (VGluT3) and SERT, were …
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Epigenetic and expression-based modifications of depression-relevant genes as peripheral biomarkers for treatment-resistant depression and major depressive disorder
… from the Detroit Neighborhood Health Study, SLC6A4 mRNA expression approached a significant association with lifetime MDD diagnosis status. Efforts to elucidate additional peripheral biomarkers should continue to expand to include polygenic CpG methylation measurements in multiple tissues.
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Quantitative Genexpressionsanalyse im respiratorischen Netzwerk an Mausmodellen für das Rett-Syndrom
… Grin2a (P7), Gabrb1 (P7), Tph2 (P7), Ddc (P40), Slc6a4 (P7), Htr4 (P7) und als Aktivator auf Grin2d (P7), Drd4 (P7), Oprm1 (P40) wirken könnte. Sehr starke Evidenzen weisen daraufhin, dass Htr5b und Foxp2 ebenfalls Zielgene von MeCP2 sind und dass MeCP2 supprimierend auf deren Expression wirkt. …
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Impact of the Serotonin-Transporter-Polymorphism (5-HTTLPR) and Stressful Life Events on the Stress Response in Humans
The 5-HTT gene (SLC6A4) is regulated by a common polymorphism in the promoter region (5-HTTLPR), which has functional consequences. Two major alleles have been observed and shown to have differential transcriptional activity with the long (L) allele having greater gene expression than the short (S) …