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Showing 1 to 2 of 2 for “"SLC25 mitochondrial carrier family"”.

  1. Functional and mechanistic studies of human mitochondrial carriers

    The SLC25 mitochondrial carrier family is the largest family of transporters, with 53 members in humans. They selectively transport a diverse set of substrates across the mitochondrial inner membrane, and are involved in key aspects of mitochondrial metabolism and function. The identification and …

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  2. Structure and regulatory mechanism of human uncoupling protein 1

    Uncoupling protein 1 (UCP1) in the mitochondrial inner membrane is responsible for the thermogenic properties of brown adipose tissue. In response to cold exposure, UCP1 is activated by free fatty acids and catalyses proton leak, dissipating the proton motive force, which mitochondria use to drive …

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