Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 9 of 9 for “"SKOV-3"”.
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Mechanistic investigation of anticancer agents that damage DNA and interact with the estrogen receptor
… crosslink formation in the ovarian cell line SKOV-3, which potentially leads to the S-phase arrest observed in these cells. Further, the arrest is persistent even after drug removal, indicating that the persistence might be one of the reasons for the enhanced toxicity of E2-7ca compared to the …
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Determining the mechanism of double-stranded RNA-induced cell death in ovarian cancer.
… found that in ovarian cancer cell lines (DOV-13, SKOV-3, CAOV-3, and OVCAR-3), dsRNA treatment alters cell survival. When treated with dsRNA, ovarian cancer cell lines and patient samples could be divided into two categories, responsive which undergo significant levels of apoptosis (CAOV-3 and …
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Expression and role of the extracellular matrix protein tenascin in ovarian cancer
… cell adhesion, spreading and migration in the SKOV-3, 59M, PE01 and PE04 ovarian carcinoma cell lines, however, fibronectin and collagen IV appeared to be preferable substrates. Immuno-staining and analysis by flow cytometry of these cell lines demonstrated that all expressed the integrin …
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Three-Dimensional Microscopy by Laser Scanning and Multi-Wavelength Digital Holography
… The 3D images of porous coal samples and SKOV-3 ovarian cancer cells are presented.
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An intraperitoneal implantable drug delivery device for the treatment of ovarian cancer
… lines was demonstrated. An in vivo xenograft SKOV-3 tumor model was established and optimized to reflect the distribution of ovarian cancer metastases in humans. The device achieved effective tumor growth retardation without systemic toxicity. An IP bolus injection scheme with a similar …
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ROR1 and Rab27b – novel biomarkers for chemoresistance in ovarian cancer
… line panel was assembled comprising of; HEY, SKOV-3, OVCAR-3 and OAW42. The IC50 doses of four drugs; cisplatin, carboplatin, taxol and talazoparib for the cell lines were determined. qPCR was carried out to investigate gene expression levels of ROR1, Rab27b and EMT markers in response to drug …
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An evaluation of cancer biomarkers in normal ovarian epithelial cells and ovarian cancer cell lines
… ovarian surface epithelial cell line (HOSEpiC), SKOV-3 cells and the OAW42 human epithelial ovarian tumour cell lines were used to evaluate the selected cancer biomarkers. Cells were cultured using appropriate media and supplements, and real-time quantitative polymerase chain reaction (RT-PCR) …
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Development and evaluation of methodologies for analysis of CTC and ctDNA in patients with ovarian carcinoma
… the CTC markers were done using OC cell lines, SKOV-3 and OVCA432. CTCs were enriched using the ParsortixTM (Angle plc.) system, and further detected using the multifluorescent markers from 16 OC patients. Patients were found to have heterogeneous CTCs, with 113/157 (72%) cells positive for …
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Design, Synthesis, and Evaluation of Oleyl-WRH Peptides for siRNA Delivery
<p>The delivery of nucleic acid therapeutics across various cell membranes has always been one of the major challenges. Cell-penetrating peptides (CPPs) containing arginine (R), tryptophan (W), and histidine (H) have been promising for siRNA delivery. Therefore, to enhance siRNA delivery and …