Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 5 of 5 for “"SK channels"”.
-
ADENOSINE SYSTEM DYNAMICS AND SK CHANNELS MODULATE BASOLATERAL AMYGDALA PYRAMIDAL CELL EXCITABILITY: IMPLICATIONS FOR ANXIETY DISORDERS AND COMORBID ETHANOL ABUSE
Alcohol use disorders (AUDs) impart serious social and economic costs on society. For example, nearly 1 in 18 Americans abuses or is addicted to alcohol, contributing nearly $234 billion per year in socioeconomic costs. Despite this, effective pharmacological treatments remain elusive. To aid in …
-
Detection of SK2 Channels on Hippocampal Neurons
<p>Calcium-activated small conductance potassium channels (SK) are crucial for synaptic plasticity, sleep, and learning and memory (Hammond, Bond et al. 2006; Cueni, Canepari et al. 2008; Lin, Lujan et al. 2008). Despite the recent progress on SK channel physiology, the precise spatial organization …
-
SK Channel Modulators as Drug Candidates and Pharmacological Tools
… and intermediate-conductance Ca2+ activated K + (SK/IK) channels play a fundamental role in the regulation of neurons in the central nervous system. In animal models, SK/IK channel positive modulators have been shown to be effective in reducing the symptoms of neurological diseases such as ataxia. …
-
Ca2+-Activated K+ Channels in Urinary Bladder Smooth Muscle: Functional Role and Potential as Therapeutic Targets for Overactive Bladder
… conditions, the opening of potassium (K+) channels causes membrane hyperpolarization and limits the entry of Ca2+ and thus decreases DSM contractility. Among the various K+ channels, Ca2+-activated K+ (KCa) channels are important in regulating DSM function. Based on their biophysical …
-
PIP2 Modulation of Afterhyperpolarizations in Magnocellular Supraoptic Neurons
… a fast component (fAHP) underlain by BK channels, a medium component (mAHP) underlain by apamin-sensitive SK channels, and a slow component (sAHP) which is an apamin-insensitive K+ conductance. The mechanisms that control the sAHP are poorly understood in MNCs. The work embodied here …