Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 18 of 18 for “"SJL"”.
-
Identifizierung und Charakterisierung von Suszeptibilitätsloci für Typ-2-Diabetes mellitus in einem Mausmodell für das Metabolische Syndrom
… mice with the lean, arteriosclerosis-resistant SJL strain was established. A total of 400 male backcross mice were monitored over a time period of 22 weeks (increment of body weight and body mass index, blood glucose, serum insulin, serum lipids). In a genome wide scan with more than 100 …
-
Positionelle Klonierung von Tbc1d1 als Kandidatengen für Adipositas
… der Mausstämme NZO (adipös) und SJL (schlank) identifiziert wurde. Um Kandidatengene für Adipositas zu finden, wurden mehr als 300 Nob1-Transkripte mit Hilfe von Genexpressionsanalysen auf Unterschiede in stoffwechselrelevanten Geweben zwischen beiden Mausstämmen untersucht. …
-
Identifikation und Charakterisierung von Suszeptibilitätsloci für Adipositas und Hypercholesterinämie in der NZO-Maus
… New Zealand obese (NZO) mouse with the lean SJL strain was established in order to locate genes responsible for obesity and the associated syndrome of insulin resistance, hyperglycemia and dyslipidemia, and to compare the effects under a standard and a high fat diet. The pattern of symptoms …
-
Patterns of intraspecific and intergeneric agonistic behavior in the male and female Mongolian gerbil (<i>Meriones unguiculatus</i>)
… a male or female gerbil or a male or female SJL mouse) were placed in the home cage. The resulting outcomes of the social interactions between the resident gerbils and the intruders revealed three important findings: (1) that SJL mice are subject to more agonistic behavior on the part of the …
-
Spatial models of plant diversity and plant functional traits : towards a better understanding of plant community dynamics in fragmented landscapes
… the study area in the Southern Judean Lowlands (SJL). For this purpose, I parameterised a multi-species incidence-function model (IFM) with vegetation data using approximate Bayesian computation (ABC). I found that the type of regional plant community dynamics in the SJL is best characterized as …
-
Differentielle hepatische Genexpression in einem Mausmodell mit polygener Adipositas, Insulinresistenz und Hyperglykämie
… outcross model of obese NZO mice with the lean SJL strain was established. NZOxF1 (SJLxNZO) backcross mice were generated in order to obtain a population with heterogeneous metabolism but comparable genetic background. Groups of normal (normoglycemic/normoinsulinemic), insulin-resistant …
-
Determinants of cns adult neurogenesis are sex, hormones, mouse strain, age, and brain region
… progenitors in 6-8wk and 6-8mo normal C57BL/6, SJL/J and BALB/c mice in the subventricular zone (SVZ), dorsolateral horn (DLC), corpus callosum (CC), and parenchyma. With a short 2 h BrdU pulse, no gender and strain differences are present at 6-8wk. At 6-8mo, the number of BrdU+ cells decreases …
-
Untersuchung genetischer und geschlechtlicher Einflüsse in der Alzheimerpathologie anhand des Maustiermodells 5XFAD
… und genetische Einflüsse zwischen dem B6- und B6/SJL-Hintergrund untersucht. Zusätzlich wurde noch eine vergleichende Untersuchung zur Aβ-Amyloid-Belastung (Plaqueload) durchgeführt. Als Kontrollgruppe dienten B6-Wildtypmäuse. Die von Oakley und Kollegen beschriebenen Verhaltensauffälligkeiten im …
-
Genetic and Sex Steroid Hormone Contributions to the Sexual Dimorphism in Murine Experimental Allergic Encephalomyelitis
… studied through the use of reciprocal crosses of SJL/J and BI0.S/SgMcdJ mice. We found that adult gonadal hormones selectively regulate sexually dimorphic quantitative traits observed in EAE at the clinical, histopathologic, and genetic levels. Furthermore, we identified specific genetic linkages …
-
Nitric oxide : cellular effects in vitro and in vivo
… of nitric oxide production and cytotoxicity SJL/J mice bearing the transplantable lymphoma RcsX have been established as an in vivo model of nitric oxide production and toxicity.
-
Nucleobase deamination as a biomarker of inflammatory processes
… deamination products were observed in the SJL mice bearing the RcsX tumor, but the biological meaning of these increases awaits studies of DNA repair kinetics. dO was not detected in any study at levels above 5 per 10⁸ nt, leading to the prediction that it will not be present at significant …
-
Untersuchungen zur Blockade des Makrophagen-Migrations-Inhibitionsfaktors in der Experimentellen Autoimmunen Enzephalomyelitis
… anti-MIF-mAK von PLPp139-151-induzierter EAE in SJL-Mäusen in der akuten Phase der Erkrankung wirkt und zu einer schnelleren Besserung im Vergleich zu Kontroll-Mäusen führt. Des Weiteren wurde gezeigt, dass das „Homing“ der pathogenen Neuroantigen-spezifischen T-Zellen in das ZNS durch die …
-
Exploring the Impact of Inclusive Education Knowledge on School Administrators' Attitudes: A Quantitative Analysis of Influencing Factors and Leadership Preparedness
… Education (DSE) and social justice leadership (SJL) framework, investigated the relationship between administrators' knowledge, source of knowledge, and attitudes toward inclusive education. To investigate how preparation programs, on-the-job, and other experiences shape attitudes toward …
-
Effects of Puberty and Obesity on Central Nervous System Autoimmunity in Experimental Autoimmune Encephalomyelitis
… EAE development was compared between age-matched SJL/J mice that differed only by pubertal status. It was observed that puberty in females, but not males, was associated with increased susceptibility to EAE. Additional studies performed in female mice revealed that myelin-specific T helper (Th) …
-
Autoregulatory CD8 T-Cells Modulate CNS Autoimmune Disease by Targeting Encephalitogenic CD4 T-Cells
… peptide (PLP₁₇₈₋₁₉₁)-induced EAE in B6 and SJL mice strains were capable of generating disease ameliorating CNS antigen-specific CD8 T-cells. Autoreactive regulatory (autoregulatory) CD8 T-cells exhibit a central memory phenotype (CCR7+CD62L+CD44-) and produce IFN-γ and perforin. Disease …
-
Microarray-basierte Expressionsanalysen des weißen Fettgewebes der NZO-Maus sowie der Langerhansschen Inseln der NZL-Maus : zwei Modelle für das metabolische Syndrom
… adipöse NZO-Modell und konnte bei der schlanken SJL Maus nicht beobachtet werden, was auf eine mögliche Beteiligung an der Entstehung der Insulinresistenz hinweist. Zusätzlich wurde bestätigt, dass die Expansion des Fettgewebes bei der adipösen NZO-Maus eine zeitlich verzögerte Infiltration von …
-
The role of central IL-6 signalling in the development of Type 2 Diabetes
… (Nes-cre) 1Kln/J mice were crossed with B6 (SJL)-Il6ratm.1.1Drew/J animals (IL-6Rflox/flox). The Nestin promoter exhibits brain-specific expression, while the IL-6R gene is flanked by 2 loxP sites in IL-6Rflox/flox mice that would theoretically allow for brain-specific disruption of the …
-
Aspects of the Immunobiology of Myelin Oligodendrocyte Glycoprotein (MOG)-induced Experimental Autoimmune Encephalomyelitis (EAE)
… BN rats (Stefferl et al., 2000), as well as in SJL/J, C57/BL6, DBA.1 and CBA.1 mice (Schubart and Wissing, unpublished results). In addition, despite the presence of regions with a high level of sequence identity between the two proteins it was not possible to induce a significant cross-reactive …