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Showing 1 to 8 of 8 for “"SIX1"”.
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Genomic characterization of Six1 function during skeletal muscle differentiation
… factors counts six members in vertebrates (from Six1 to Six6). Six1 is important for skeletal muscle development: Six1-/- mouse neonates die at birth because of severe muscle hypoplasia. However, the molecular targets of Six1 are poorly characterized systematically. The Myogenic Regulatory …
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Six1 Is Important for Myoblast Proliferation Through Direct Regulation of Ccnd1
The transcription factor Six1 of the sine oculis homeobox family has been tied to skeletal muscle formation. Work completed thus far has allowed our research team to identify the precise mechanism by which Six1 regulates the expression of MyoD, a key myogenic gene, in muscle stem cells. …
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Sine Oculis Homeobox Homolog 1 (Six1) Plays A Critical Role In The Progression of Pulmonary Fibrosis.
… gene, Sine Oculis Homeobox Homolog 1 (Six1), which is a transcription factor that is essential for normal lung morphogenesis <em>in utero</em> that I show to be inappropriately expressed in the AT2 cells in IPF.</p>
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Adipocytes and Innate Immunity In Systemic Sclerosis
… gene sine oculis homeobox homolog 1 (SIX1) in skin-associated adipocytes in SSc skin and the early loss of dermal white adipose tissue (DWAT). We validated the mammalian expression of Six1 in murine dermal adipocytes, and using two transgenic models lacking Six1, we demonstrate that …
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Identification, Validation and Implementation of Blastemal Biomarkers in Wilms Tumour
… most specific expression in blastemal cells were SIX1 and CITED1. These proteins are transcription factors expressed during kidney development and both were shown to be highly expressed in the blastemal element of WT (89% and 100%, of WT cases, respectively). SIX1 and CITED1 also displayed some …
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FROM A PLACODE PROGENITOR PLATFORM TO A TRIGEMINAL GANGLION ORGANOID: MODELLING SENSORY DEVELOPMENT AND FUNCTION IN VITRO
… by the expression of the transcription factor SIX1, and which gives rise to most of the facial peripheral nervous system. The intermediate region of the pre-placodal ectoderm later acquires a trigeminal fate, marked by the expression of PAX3, and thus develops into the TG. The TG is involved in …
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Functional Genomics Characterization of Six4 During Skeletal Myogenesis
… role for Six4 during muscle development as Six1;Six4 double mutant mice show a more severe muscle phenotype than Six1 mutant mice. Nevertheless, the role of Six4 during adult muscle regeneration has never been addressed. I combined a partial loss-of-function of Six4 with high-throughput …
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Development of the Inner Ear: a Molecular, Cellular and Evolutionary Approach to Understanding the Development of the Inner Ear with an Emphasis on the Roles of Fgf10 and Foxgl
… oto-renal (caused by mutations in Eya1 and Six1), Waardenburg’s (mutations occur in the Pax3 and MITF genes, among others), Pendred's (caused by a mutation in the PDS /pendrin gene) and Usher’s (caused by a mutation in one of several USH genes) Syndromes. In addition, over 70 different genes …