Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 11 of 11 for “"SIV infection"”.
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Virus tropism and neutralization response in SIV infection
Simian immunodeficiency virus (SIV) infections in macaques are commonly used as models to study the pathogenesis of human immunodeficiency virus (HIV). Both SIV and HIV normally use the CD4 receptor and an additional coreceptor for cell entry. The most common coreceptors used by HIV are CCR5 and …
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Impact of Thymectomy on the Peripheral T Cell Pool in the Context of SIV Infection
… context of human immunodeficiency virus (HIV)-1 infection, in which the progressive loss of CD4+ T cells leads to immunodeficiency and opportunistic infection. CD4+ T cell loss is thought to result from direct and indirect killing of CD4 cells in the periphery as well as from pathogenic effects …
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Assessment of Gamma/Delta T Cell Functionality Following Pathogenic HIV/SIV and Non-Pathogenic SIV Infections
Pathogenic HIV/SIV infection induces high viral loads, aberrant immune activation, and dysfunction in numerous immunologic cells (including gamma/delta (gamma delta ) T cells) leading to opportunistic infections. gamma delta T cells bridge the innate and adaptive immune responses primarily via …
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Distinct Patterns of Ccr5 Versus Alternative Coreceptor Dependence in Non-Natural Host Versus Natural Host Simmian Immunodeficiency Virus Infection
… infected with simian immunodeficiency viruses (SIV) exhibit high plasma viral loads without widespread CD4+ T cell loss. By contrast, non-natural host rhesus macaques experimentally infected with related SIV exhibit high viral loads but display subsequent CD4+ T cell loss and progression to …
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Kinetik von NK-Zellen und gamma-delta-T-Zellen nach Infektion von Rhesusaffen mit Immundefizienzviren
Human immunodeficiency virus (HIV) infection and the caused acquired immunodeficiency syndrome (AIDS) developed over the last 25 years to a pandemic. In 2006 more than 39 Million people were HIV positive. Based on the high concordance with the human and viral system, rhesus macaques infected with …
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Assessing the Efficacy of Interleukin-7 as an Immunotherapeutic in the SIV+ Rhesus Macaque Model
Human Immunodeficiency Virus (HIV) infection is known for depleting ‘helper’ CD4+ T cells. Highly active antiretroviral therapy (HAART) reduces viremia and increases CD4+ levels, however, 5-20% of patients fail to reconstitute CD4+ T cell levels despite viral suppression. Interluekin-7 (IL-7), a …
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The impact of sexually transmitted infections and inflammation in the female genital tract and blood on susceptibility to HIV-1 infection and disease progression
… prevalence of HIV-1 worldwide, most newHIV-1 infections occur by sexual transmission to women. Recent studies in non-human primates have demonstrated that pro-inflammatory cytokine production in the genital tract is necessary for immune cell recruitment and establishment of simian …
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Novel strategies for characterizing T Cell responses in SIV-infected rhesus monkeys
… immune system to defend the host against common infections. While anti-retroviral therapy has decreased morbidity and mortality, these drugs are not curative. In addition, they are beyond the financial reach of many HIV infected patients. Thus, the development of strategies to control HIV spread …
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Study of the Immune Correlates of Protection in Rhesus Macaques Vaccinated against Simian Immunodeficiency Virus
… trial provided evidence of protection from virus infection, with 31.2% of the patients protected at three years since the end of the immunisation phase. Statistical analyses support serum IgG antibody recognition of the V2 region of viral gp120 as a mechanism of protection from acquisition. One …
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The G-protein coupled receptor CMKLR1/ChemR23: Studies on gene regulation, receptor ligand activation, and HIV/SIV co-receptor function
… and simian immunodeficiency virus (HIV-1 and SIV)-infection of CD4+ immune cells. We have described the genomic organization of cmklr1 in mouse and analysed the regulatory mechanism behind the corresponding receptor expression. Two transcripts of mouse cmklr1 have been identified, cmklr1a and …
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Charakterisierung der angeborenen Immunantwort in SIV-infizierten Rhesusaffen
… der APOBEC3-Expression auf den Krankheitsverlauf SIV-infizierter Rhesusaffen, dem wichtigsten Tiermodell für AIDS. Dafür wurden die A3G- und A3F-Transkriptionsraten zu verschiedenen Zeiten im Krankheitsverlauf mit real-time-PCR in einigen Zellpopulationen des Blutes sowie in den Zellen der …