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Showing 1 to 8 of 8 for “"SIRT6"”.
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SIRT6 Overexpression Protects Against Diet-Induced Diabetes in Mice
… nuclear proteins (2). Initial studies involving SIRT6, one of three nuclear sirtuins, suggest that it may be an attractive drug target for obesity and type-II-diabetes therapy. Knockout studies indicate that SIRT6 is required for normal growth, adiposity, and glucose homeostasis (3). Yet, …
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USING CHEMICAL AND PROTEOMICS APPROACHES TO STUDY THE FUNCTIONS OF SIRT6 AND KRAS
… play a variety of roles in biological systems. SIRT6 is one of the seven mammalian sirtuins and has diverse biological functions such as maintaining genomic stability, controlling glucose homeostasis and suppressing tumor growth. Enzymatically, SIRT6 has been shown to have lysine deacetylation, …
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Mdm2-Mediated Degradation of Sirt6 Phosphorylated By Akt1 Promotes Tumorigenesis and Trastuzumab Resistance In Breast Cancer
<p>Sirtuin6 (SIRT6) is one of the members of the Sirtuin family and functions as a longevity assurance gene by promoting genomic stability. It also regulates various cancer-associated pathways and was recently established as a bonafide tumor suppressor in colon cancer. This suggests that SIRT6 is …
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Mechanistic Elucidation of the Function of Sirtuin 6 in the Regulation of Liver Fibrosis
… unclear. Here we have identified Sirtuin 6 (SIRT6), an NAD+ dependent deacetylase, as a key epigenetic regulator in the protection against hepatic fibrosis by suppressing the YAP/TAZ activity. SIRT6 has been previously implicated in the regulation of the canonical transforming growth factor β …
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Study of Mutations and Expression of Genes Correlated to the Appearance of Colorectal Cancer /// Проучване на мутации и експресия на гени, корелиращи с изявата на колоректален карцином
… tumours. • Analysis of the expression levels of SIRT6, FOXO4 and HIF3A genes of all patients’ tumours compared to healthy colon tissue and correlation to RAS mutational status and according to patient staging. • Correlation between the expression of SIRT6, FOXO4 and HIF3A genes in all patients’ …
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The Role of FOXO3 in Mechanisms of Doxorubicin Resistance in Hepatocellular Carcinoma
… doxorubicin resistance. The expression of SIRT6, a known FOXO3 deacetylase, was also increased in TACE-resistant HCC tumors and correlated with cytosolic FOXO3. SIRT6 also blocked doxorubicin-induced S574-phosphorylation of FOXO3 and increased resistance to doxorubicin in Huh7 cells. …
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Nicotinamide Riboside Delivery Generates NAD+ Reserves to Protect Vascular Cells Against Oxidative Damage
… were abrogated upon SIRT1 knock-down (KD). SIRT6 KD was similarly implicated in NR-mediated DNA repair. Furthermore, NR delivery protected against oxidative-stress-induced senescence. This protection was partially lost by SIRT1 KD. NR delivery protects vascular cells from H2O2–induced cell …
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DHHC PROTEIN ACYLTRANSFERASES CATALYZES THE LYSINE PALMITOYLATION OF MEMBERS OF THE RAS SUPERFAMILY OF SMALL GTPASES
… to work by Jiang et al with their discovery that SIRT6 can defatty-acylate TNFα and regulate its secretion, providing the first example for the function of protein lysine fatty acylation in mammalian cells 1,2 . Additional substrates such as K-Ras4a, and RRAS2 further highlight the importance of …