Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 4 of 4 for “"SIRT5"”.
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TUMOR PROMOTING FUNCTIONS FOR THE METABOLIC REGULATOR SIRT5
… three mitochondrial sirtuins, SIRT3, SIRT4, and SIRT5. Among these, SIRT5 is the only known enzyme that catalyzes nicotinamide adenine dinucleotide-dependent demalonylation, desuccinylation and deglutarylation. SIRT5 impacts diverse metabolic pathways. One substrate of SIRT5 is carbamoyl …
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Regulation of Mitochondrial Sirtuins Sirt3 and Sirt5 by Small Molecules
… compounds on mitochondrial sirtuins Sirt3 and Sirt5 using structural characterization as well as biochemical and biophysical analysis. Resveratrol, a polyphenol found in red wine, was reported to activate Sirt1. Testing resveratrol and its related compounds including piceatannol, polydatin, …
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A Study Of Novel Activities Of Type Iii Sirtuins: Cobb And Pfsir2A
… of other cellular functions. The discovery of Sirt5's, a type III mammalian sirtuin,novel desuccinylase/demalonylase activity opened up new possibilities of cellular protein regulation. Two conserved active site residues, Tyr and Arg, are believed to be responsible for Sirt5's …
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Biochemical and structural characterization of Sirtuins from mammals and Thermotoga maritima
… integrity of Sirtuins. Investigations on Sirt5, also a mitochondrial Sirtuin appears to indicate that it is insensitive to nicotinamide (a physiological inhibitor of Sirtuins). Studies on the nucleolar isoform Sirt7 identified Thr224 to be phosphorylated, and play a role in the enzyme’s …