Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 12 of 12 for “"SIRT3"”.
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Regulation of Mitochondrial Sirtuins Sirt3 and Sirt5 by Small Molecules
… biological functions. Three sirtuin isoforms, Sirt3-5, are located in the mitochondria and play significant roles in all mitochondrial processes. This study investigates the modulations of small molecule compounds on mitochondrial sirtuins Sirt3 and Sirt5 using structural characterization as …
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The roles of diet and SirT3 levels in mediating signaling network changes in insulin resistance
… diets mediate insulin sensitivity and the role SirT3 plays in high fat diet-induced insulin resistance. Insulin resistance is defined as the inability of cells and tissues to respond properly to ordinary amounts of insulin and is a precursor to many metabolic diseases such as diabetes and …
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Broad Remodeling of the Acetylproteome by SIRT3 Manipulation Fails to Affect Insulin Secretion or β-cell Metabolism in the Absence of Dietary Overnutrition
<p>SIRT3 is an NAD+-dependent mitochondrial protein deacetylase purported to influence cellular and systemic metabolism through modulation of the mitochondrial acetylproteome. Fuel-stimulated insulin secretion from pancreatic islets involves mitochondrial metabolism and might be susceptible to …
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Mitochondrial protein acetylation and left ventricular function in a model of hypertrophic cardiomyopathy and heart failure
… protein acetylation and impaired sirtuin 3 (SIRT3) deacetylase activity. Protein acetylation is an important regulator of cardiac metabolism and SIRT3 is protective in heart disease. The underlying pathophysiology of heart failure in FRDA is unclear. I suspect that increased acetylation in …
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Protective effect of Nicotinamide on High glucose (HG)/Palmitate (PA)-induced Glucolipotoxicity to INS-1 beta cells
… reduced HG/PA-induced cell death. Knockdown of Sirt3 or Sirt4 protected HG/PA-induced viability reduction and HG/PA-induced DNA fragmentation. In contrast, overexpression of Sirt3 or Sirt4 augmented HG/PA-induced cell death. NAM reduced the level of HG/PA-induced ER stress maker such as …
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Uncoupling Lipid Metabolism from Inflammation in Adipose Tissue
… uncoupling protein 2 (UCP2) and Sirtuin 3 (Sirt3) as important mediators of the anti-inflammatory phenotype in FABP4 deficient macrophages. Increased expression of UCP2 in FABP4 null macrophages contributes to both suppressed inflammation and endoplasmic reticulum stress (ER stress) by …
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Development and Characterization of Pre-Clinical Epilepsy Models to Evaluate Potential Anti-Seizure Targets.
… of PPARγ regulated histone deacetylates (SIRT3), anti-oxidants (SOD1), and mitochondrial solute carriers (FABP7 and SLC25a1). However, PPARγ modulators that block ser273 phosphorylation in adipose tissue could not block this phosphorylation in the hippocampus, and ser273 phosphorylation …
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NAD+ salvage by Nicotinamide phosphoribosyltransferase (Nampt) mediates lipogenesis, energy homeostasis, and survival in prostate cancer
… deacetylases by Sirtinol treatment, or SIRT1/SIRT3 knockdown, phenocopied the effects of Nampt blockade on fatty acid synthesis thereby suggesting that Nampt maintains lipogenesis through sirtuin-dependent mechanisms. Additionally, we made the novel observation that Nampt inhibition causes …
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Investigating the protective role of the natural hormone Melatonin, in reducing drug-induced cardiotoxicity in the therapy of chronic diseases
… (UCP2, PPARɣ, Drp1, Mfn1, Parp 1, Parp2, Sirt3 and Cav3), apoptosis (Bcl2 and Bcl-xL), cardiac electrophysiology and arrhythmia (Scn5a, SERCA2a), calcium handling (SERCA2a) and cardiac remodelling (Myh7, ms1). Melatonin pre-treatment attenuated or completely blocked this DOX-induced …
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Biochemical and structural characterization of Sirtuins from mammals and Thermotoga maritima
… drugs. Studies on the mitochondrial isoform Sirt3 revealed that Zinc is essential for the structural integrity of Sirtuins. Investigations on Sirt5, also a mitochondrial Sirtuin appears to indicate that it is insensitive to nicotinamide (a physiological inhibitor of Sirtuins). Studies on the …
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UNDERSTANDING THE RAL GTPASES: THE REGULATION BY PROTEIN LYSINE FATTY ACYLATION, SIRT2, AND INTERACTING PROTEINS
… of SIRT2, although it can also inhibit SIRT1 and SIRT3. I was interested in developing chemical proteomic tools to identify lysine fatty-acylated proteins. Through our proteomic studies aimed at identifying HDAC lysine fatty acylation substrates, we found that JAM-C has DHHC7-regulated cysteine …
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TUMOR PROMOTING FUNCTIONS FOR THE METABOLIC REGULATOR SIRT5
… mammals there are three mitochondrial sirtuins, SIRT3, SIRT4, and SIRT5. Among these, SIRT5 is the only known enzyme that catalyzes nicotinamide adenine dinucleotide-dependent demalonylation, desuccinylation and deglutarylation. SIRT5 impacts diverse metabolic pathways. One substrate of SIRT5 is …