Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 12 of 12 for “"SIRT2"”.
-
Charakterisierung kernständiger Funktionen der NAD+-abhängigen Deacetylase SIRT2
The human Sirtuin SIRT2 is a deacetylase predominantly found in the cytoplasm during the cell cycle, which co-localizes with the chromatin at the G2/M transition. During this transition SIRT2 was described) to deacetylate lysine-16 of histone 4. Due to the sufficient nuclear export of SIRT2 its …
-
Die humanen Sir2-Ortholoe SIRT1 und SIRT2 als Substrate Cyclin-abhängiger Kinasen
SIRT2 is a NAD+-dependent deacetylase, one of seven human sirtuins. The main characteristic of the sirtuins is their catalytic domain of 200 to 275 amino acids, also sirtuin-homology domain. SIRT2 is a predominantly cytoplasmatic protein, which co-localises with microtubules of the cytoskeleton. In …
-
UNDERSTANDING THE RAL GTPASES: THE REGULATION BY PROTEIN LYSINE FATTY ACYLATION, SIRT2, AND INTERACTING PROTEINS
… acylation is reversible and can be removed by SIRT2. Lysine fatty acylation promotes RalB GTP binding and cell migration. To further understand the differential functions of RalA and RalB, in a second study (Chapter 3), we used a quantitative proteomic approach (stable isotope labeling of amino …
-
Regulation of AMPA receptor acetylation and translation by SIRT2 and AMPK: the molecular mechanisms and implications in memory formation
… protein kinase (AMPK) and sirtuin 2 (SIRT2), are described. It is shown that SIRT2, a NAD+-dependent protein deacetylase, directly controls AMPAR stability by regulating AMPAR acetylation. For the first time, we discovered that AMPARs are subject to lysine acetylation, a novel form of …
-
Development Of Novel Radiotracers For Pet Imaging Of Hdac-Mediated Epigenetic Regulation
… </p> <p>Herein, HDAC class IIa, SIRT1 and SIRT2-selective radiotracers have been developed and validated through in vitro and in vivo characterization. Two of these tracers, 18F-TFAHA for HDAC class IIa and and 2-[18F]PhAHA for SIRT1, have also been validated in a disease model …
-
Effetto dell’esposizione cronica volontaria di eroina e WIN55,212-2 sull’espressione di micro RNA nelle aree cerebrali coinvolte nella dipendenza da sostanze d’abuso
… CLOCK, FC=3.44; DRD3, FC=4.23; NOS2, FC=6.75; SIRT2, FC=11.53; NOS1, FC=11.05; MECP2, FC=11.03; SIRT1, FC=6.30; OPRM1, FC=3.89) and 1 downregulated (BDNF, FC=-2.23). We identified only 1 gene downregulated in the prefrontal cortex (BDNF, FC=-2.15). No changes were observed in NAc shell. Protein …
-
Novel bisnaphthalimidopropyl polyamine derivatives: their mode of action in a breast cancer cell system.
… using HDAC assay kits, as a potent and selective SIRT2 enzyme inhibitor, thus, identifying, a novel structural backbone for the selective inhibition of HDAC enzymes.
-
Evaluation of the mechanisms of neurotoxcity using metabolomic strategies
… increase in the production of five genes Mlh1, Sirt2, MeCP2, UNG and TDG in both cell lines. These genes are related to DNA strand breakage, hypoxia, methylation and base excision repair.;Cultured primary hepatocytes were able to metabolise mephedrone and produce many of the metabolites produced …
-
Targeting histone deacetylase (HDACs) enzymes with novel bisnaphthalimidopropyl derivatives (BNIPs) as alternative breast cancer therapies.
… and BNIPDaCHM was identified as a potential SIRT2 inhibitor, in SKBR-3 cells. According to Proteome Profiler Arrays, BNIPDaCHM and BNIPPiEth altered the expression of cell stress-related proteins in a cell dependent manner and bioinformatic analysis revealed two novel, putative pathways for …
-
DHHC PROTEIN ACYLTRANSFERASES CATALYZES THE LYSINE PALMITOYLATION OF MEMBERS OF THE RAS SUPERFAMILY OF SMALL GTPASES
… as lysine fatty acylation through the use of the SIRT2 in-vitro defatty-acylation assay and mutagenesis of the modification sites and P-32 NAD + assay. Knockdown of the zDHHC7 gene was able to perturb the lysine fatty acylation of KRAS4A. Screening additional GTPases, not known to have lysine …
-
The potential application of rapeseed pomace extracts in the prevention and treatment of neurodegenerative diseases.
… to down regulate cell stress associated proteins SIRT2 and SOD2. In the C. elegans nematode model, the RSP extract showed no toxicity up to 5 mg/mL. The RSP extract was able to improve the disease phenotype in the MJD model (motility deficiency) as well as in all three PD models (dopaminergic …
-
Regulation of polarised trafficking by Klp98A
… p-21 activated kinase 1 (Pak1) and Sirtuin 2 (Sirt2), resulted in symmetric endosome segregation despite an asymmetric landscape of microtubule tracks. In the case of Pak1, this endosomal phenotype appeared to arise due to a delay in the targeting of endosomes to the central spindle, either …