Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 9 of 9 for “"SIRPα"”.
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Molecular mechanisms involved in the regulation of beta-cell viability by Signal Regulatory Protein-Alpha (SIRPα)
… data suggested that Signal Regulatory Protein-α (SIRPα) also plays a vital part in this protective effect. However, the protective mechanisms by which SIRPα sustains β-cell viability are poorly understood. Recently, it has been proposed that histone deacetylase 6 (HDAC6) binds to SIRPα, and that …
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The role of signal regulatory protein alpha in regulating macrophage subset activity in homeostasis and inflammation
… subsets express signal regulatory protein alpha (SIRPα), receptor to CD47. Characterised as a “don’t eat me” signal, SIRPα-CD47 ligation negatively regulates Mφ phagocytic activity. This study developed a co-culture system between CD47+ HL-60 and K562 cells, and SIRPα+ Mφ subsets in order to …
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Strategien zur Verstärkung der antikörpervermittelten Effektorzellaktivierung beim Multiplen Myelom
… mit einem immunmodulatorischen Fusionsprotein SIRPα-Fcσ kombiniert, welches die Phagozytose-hemmende Interaktion zwischen dem signal regulatory protein (SIRP) α auf Makrophagen und seinem Liganden CD47 blockiert. Dara-DE und SIRPα-Fcσ wurden mit rekombinanter DNA-Technik generiert, in …
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Identification of tumour microenvironment-derived signals that modulate the development and functionality of MDSCs
… of MDSCs, focusing mainly on the role of the SIRPα-CD47 signalling axis. In an orthotopic melanoma model, we observed an increase in Ly6C-expressing myeloid cells (indicating monocytic-myeloid derived suppressor cells (M-MDSCs) and monocytic dendritic cells (moDC)) as tumours developed. These …
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Discovery of Anti-CD47 Peptides for Cancer Immunotherapy and CD47-mimicking Peptides That Inhibit Phagocytic Clearance of Nanoparticles
… Innate checkpoint inhibitors including CD47/SIRPα antagonists, are now being developed as new strategy for cancer immunotherapy. In addition, CD47 is also known as ‘‘marker of self’’, as it is naturally presented by all cells in the body especially RBCs. This feature was first demonstrated by …
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The Development Of Multivalent Nano-Self Peptides As Antagonists For Antibody-Dependent Macrophage Phagocytosis
… ‘self’ cells, and the macrophage immune-receptor SIRPα. Upon binding to CD47, SIRPα delivers “do not eat me” signals to the macrophage allowing the contact cell or particle to evade engulfment. Cancer cells, which are abnormal human cells, express, and sometimes over-express CD47, which is one …
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Atr-Mediated Cd47 and Pd-L1 Upregulation Restricts Radiotherapy-Induced Immune Priming and Abscopal Responses In Colorectal Cancer
… to radiotherapy, which through engagement of SIRPα and PD-1 suppresses the capacity of antigen-presenting cells to phagocytose them thereby preventing TAA cross-presentation and innate immune activation. This post-irradiation CD47 and PD-L1 upregulation can be observed across various human …
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Anti-CD47 targeting therapy for the treatment of colon and pancreas cancers.
… blocking CD47's interaction with its ligand SIRPα allowed for phagocytosis of colorectal and pancreas tumors by macrophages. In some models, treatment of xenotransplanted tumors in immunodeficient mice with anti-CD47 antibodies strongly reduced tumor growth. In other models, the combination …
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Leveraging Innate Immune Sensors to Generate Durable Anti-Glioma Adaptive Immune Responses
… PD-L1 upregulation across the myeloid stroma and SIRPα upregulation specifically in brain resident microglia. We found that STING activation enhances microglial phagocytic capacity, and that CD47 blockade further enhances microglial phagocytosis of glioblastoma cells. Combined STING activation and …