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Showing 1 to 8 of 8 for “"SIRP"”.
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The Relevance of the SIRP Protein Family to Signal Transduction and Cell Adhesion
The SIRPs are a recently discovered family of glycoproteins comprising more than 30 members belonging to the immunoglobulin superfamily. The two different structural subtypes, termed SIRP α and SIRP β, are distinguished by the presence or absence of a cytoplasmic domain, respectively. SIRP α1, the …
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Modulating SIRP-alpha, a Myeloid-Specific Immune Checkpoint, for Immunotherapeutic Treatment of Malignancy
The general metadata -- e.g., title, author, abstract, subject headings, etc. -- is publicly available, but access to the submitted files is restricted to UT Southwestern campus access and/or authorized UT Southwestern users.
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Regulation of IL-6 signal transduction, contributions of the Signal Regulatory Protein (SIRP) and cyclic AMP
… “signal regulatory protein/SHP-substrate” (SIRP alpha/SHPS-1) has been implicated in growth factor- and cell adhesion-induced signalling. In the first part of this thesis it is shown for the first time that SIRP alpha contributes to IL-6-type cytokine signalling. SIRP alpha binds to the …
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Strategien zur Verstärkung der antikörpervermittelten Effektorzellaktivierung beim Multiplen Myelom
… mit einem immunmodulatorischen Fusionsprotein SIRPα-Fcσ kombiniert, welches die Phagozytose-hemmende Interaktion zwischen dem signal regulatory protein (SIRP) α auf Makrophagen und seinem Liganden CD47 blockiert. Dara-DE und SIRPα-Fcσ wurden mit rekombinanter DNA-Technik generiert, in …
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Klonierung und Charakterisierung von Signal Regulatory Protein beta in primären Makrophagen der Maus
�Signal Regulatory Proteins� (SIRP) sind glykosylierte Transmembran-Proteine, gehören zur Immunglobulin-Superfamilie und werden von zahlreichen Zellen des hämatopoetischen Sys-tems, Nervenzellen und Fibroblasten exprimiert. Sie werden in 2 Gruppen, SIRPa und SIRPb unterteilt. Vertreter der SIRPa …
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Anti-CD47 targeting therapy for the treatment of colon and pancreas cancers.
… blocking CD47's interaction with its ligand SIRPα allowed for phagocytosis of colorectal and pancreas tumors by macrophages. In some models, treatment of xenotransplanted tumors in immunodeficient mice with anti-CD47 antibodies strongly reduced tumor growth. In other models, the combination …
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Chimeric Thrombomodulin and CD47 proteins synergistically improve the engraftment of islets by mitigating IBMIR
… CD47 binds to signal regulatory protein alpha (SIRP[alpha]), delivering a "do not eat me signal" to suppress phagocytosis and inhibition of myeloid cell activation. Hence, we hypothesized that SA-TM and SA-CD47 combination on islets maintain islet engraftments in a syngeneic marginal mass model …
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Role of CD47 In Red Cell Apoptosis (Eryptosis)
… them to escape immune surveillance by binding to SIRP alpha on macrophages. The aims of this thesis were to evaluate and to confirm the presence of CD47 isoforms in erythroid and erythroleukemic cells, identify new CD47 binding proteins that may mediate the phosphatidylserine exposure pathway …