Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 5 of 5 for “"SIN-1"”.
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XRCC1 & DNA MTases : direct and indirect modulation of inflammation-induced DNA damage
… following exposure to the peroxynitrite donor, SIN-1 and to NO*. Using the alkaline comet assay, we find that while XRCC1 proficient and deficient CHO cells incur equivalent levels of SIN-1 induced BER-intermediates, the XRCC1 null cells are more sensitive to killing by SIN-1, as assessed by …
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The Novel Function of Creatinine Acting as an Anti-Inflammatory Immunomodulator and Antioxidant
… enhance anaerobic exercise performance by increasing phosphocreatine stores and free CR to increase adenosine triphosphate (ATP) turnover in the muscles, therefore increasing muscle mass and reducing muscle recovery time following a strenuous workout. CR hydrolyzes into creatinine (CRN) rapidly. …
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Astrocytic communication and cell death during metabolic depression and oxidative stress
… ischemic insult is not well understood. An increasing amount of evidence indicates that astrocytes are more sensitive to ischemic injury than previously thought. Astrocytic functions are vitally important for neuronal activity during physiological conditions and probably during various …
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The role of reactive nitrogen species and aged garlic extract on platelet function
… platelets, including calcium and cyclic adenosine monophosphate (cAMP). The effect of AGE upon the other cyclic nucleotide, cyclic guanosine monophosphate (cGMP) is currently unknown. The aims therefore of this project are to identify the effect of AGE upon platelet cGMP, as well as associated …
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Analysis of DNA damage and repair responses in cerium exposed cells and hepatocyte spheroids
… experiments are generally performed in vitro using cultured cells to predict responses in vivo. Due to limitations of cell culture systems, there is a growing interest in utilizing 3D cell culture models to better mimic conditions found in tissues. This thesis investigates the DNA damaging …