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Showing 1 to 20 of 21 for “"SIMCA"”.
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Einsatz der FT-IR-Mikrospektroskopie und multivariater Auswertealgorithmen zur Identifizierung und Klassifizierung von Tumorgeweben
… Spektren zu diesen Modellen wurde ein SIMCA-Klassifikations-Algorithmus entwickelt sowie ein LDA-Algorithmus eingesetzt. Für beide Methoden wurde die Klassi-fikations-Leistung anhand der Spezifität und Sensitivität bestimmt. Beide Klassifikations-Algorithmen führten zu guten …
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A metabolomics approach for targeted isolation and production of bioactive secondary metabolites in microbial isolates from extreme environments
… evaluated by multivariate analysis in SIMCA v15.02. Orthogonal partial least squares discriminant analysis (OPLS-DA) in SIMCA was used to predict and pinpoint the biologically active secondary metabolites. Up-scaling was optimised to increase the production yield of the target …
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Metabolomic modelling and applications in inflammatory bowel diseases
… with various scaling and transformation methods. SIMCA-P 14 was used to evaluate the model parameters for each pre-treatment method.In this thesis, metabolomics was employed in various studies to assess metabolite biomarkers associated with healthy controls and IBD diseases. All the studies …
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Development of a Pharmaceutical Tablet Authentication system using Spectroscopic Techniques in combination with Multivariate Chemometric Methods
… soft independent modeling of class analogy (SIMCA) method. Hence, the support vector data description (SVDD) method—which has no distribution assumption—is proposed for use as a class modeling approach for authentication purposes. Implementing the SVDD algorithm improved model performance by …
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The characterization of olive oils by various chromatographic and spectroscopic techniques
… by soft independent modelling of class analogy (SIMCA) respectively.<br/>
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Differenzierung von humanen Plattenepithelkarzinomen mittels IR-mikrospektroskopischem Imaging
… zur Spektrendifferenzierung und die SIMCA (Soft Independent Modelling of Class Analogies) zur Spektrenklassifizierung. Die Validierung der Ergebnisse erfolgt über die histologische Untersuchung der nach der spektroskopischen Messung gefärbten Gewebedünnschnitte. Die genaue …
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Evaluation of Flavor Variation in Swiss Cheese from Five Factories Using Selected Ion Flow Tube Mass Spectrometry (SIFT-MS), Descriptive Sensory Analysis, and Consumer Testing
… Soft Independent Modeling of Class Analogy (SIMCA) indicating unique flavor profiles. A variety of variables inherent to Swiss cheese manufacture may contribute to the variation in flavors associated with each factory. This study provided end point flavor characteristics and compounds to be …
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Metabolic profiling of cyanobacterial extracts using multivariate data analysis for their anti-obesity properties
… data evaluation. MVDA was performed utilizing SIMCA software. Principal component analysis (PCA) and orthogonal partial least squeares discriminant analysis (OPLS-DA) were applied to explore if there was any difference between strains which were „active“ versus „non-active“. Several biomarkers, …
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Metabolomic profiling to investigate effect of curcumin in lung cancer
… using multivariate data analysis software, SIMCA P+. Principal Component Analysis (PCA) score plots showed clear significant (p < 0.05) separation between the cancer and control groups. The metabolites responsible for the differences between the two groups as observed from the PCA loading …
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Application of chemometric analysis to UV-visible and diffuse near-infrared reflectance spectra.
… a soft independent modeling of class analogy (SIMCA) in order to classify the samples according to fiber type. The samples in the study had no pretreatments. The discriminating power of these models was tested by creating validation sets within a given fiber type as well as attempting to …
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The use of metabolomics tools to assess the therapeutic natural products of honey and propolis from Malaysia and New Zealand
… least squares discriminant analysis (OPLS-DA) in SIMCA-P 14.0 to predict and pinpoint the plausible bioactive components against respective cancer cell lines. The chemical profiling of honey from Malaysia and New Zealand were also obtained using the same metabolomics approach.;However, isolation …
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Application of Fourier-transform Infrared (FTIR) for Quality Control of Swiss Cheese
… Soft independent modeling of class analogy (SIMCA) was used to develop different classifications with infrared spectra. This study has shown that FTIR, coupled with water extraction, was a useful tool to monitor changes occurring in Swiss cheese making, for split formation and cheese …
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A collective self-governance framework for urban facilities management settings: application at public transport interchanges in economically depressed areas in Cape Town
… the Social Identity Model for Collective Action (SIMCA), Place Attachment Theory, and Elinor Ostrom's Design Principles for Self-Governance of Common-Pool Resources to form the theoretical framework. The merging of these three theories produced five critical constructs that were utilised to …
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Metabolomic comparison of selected Helichrysum species to predict their antiviral properties
… species from this study was analysed using the SIMCA-P software to discriminate between the different species on the basis of their bioactivity and chemical composition. The samples did not group well on Principal Component Analysis (PCA) but did separate well using the Orthogonal Projection to …
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The fate of fluorescent whitening agents in the aquatic environment
… unsuccessful.<br/><br/>Using computer modelling (SIMCA), combined with ultraviolet absorbance measurements, it was possible to determine the concentration of the Blankophor in filtered activated sludge solution. Biodegradation studies were undertaken with the Blankophor using this method to …
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Process analytical technology in tablet manufacturing
… space. Moreover, multivariate analysis software (SIMCA), was involved in order to extract multivariate spectroscopic data to be comparable form such as Principal component analysis (PCA). This formulation contained two active pharmaceutical ingredients (API), Paracetamol and Caffeine, while others …
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The application of metabolomics in human health and disease
… (PCA-X) and supervised (OPLS-DA) models in SIMCA in order to determine discriminating metabolite biomarkers responsible for the observed clustering patterns. Investigation of metabolomic effects of an 80 km ultramarathon exercise among healthy volunteers on a treadmill gave clear separation …
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The use of hair detect (and monitor) chronic hyperglycaemia
… were analysed using statistical software (SIMCA, Umetrics) to determine whether the hair of diabetics was distinguishable from hair of healthy controls as well as whether spectra correlated with HbA1c levels of participants. Hair amino acid concentrations were also analysed as it is known …
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Anti-Cancer Effects Of Garcinol In Pancreatic Cancer Transgenic Mouse Model
… spectroscopy was performed on Varian-500S. Simca P+ and CHENOMX NMR suite were used for Metabolomic analysis of urinary spectra. <strong>Results</strong>, Dietary Garcinol arrests the Progression of Pancreatic Cancer <em>invivo</em> in KRAS and p53 pancreas- specific mutant mouse model. All …
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Application of Multivariate Statistical Methods to the Analysis of Ancient Turkish Potsherds
Made available in DSpace on 2017-07-06T18:55:18Z (GMT). No. of bitstreams: 3 Martin_Rodger_C_MS.pdf: 58099985 bytes, checksum: 00dc5708081ea2b46d58591ad3db49f7 (MD5) Martin_Rodger_C_MS_ABS.pdf: 474812 bytes, checksum: e3cd6f4d6dde1941fa7d7531206f25e5 (MD5) license.txt: 4813 bytes, checksum: …
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