Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 3 of 3 for “"SIK3"”.
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Protein kinases in hormonal regulation of adipocyte metabolism.
… we find that salt-inducible kinase 3 (SIK3), a kinase that belongs to the AMPK-related family of kinases, and displays structural similarities to AMPK, can be regulated by catecholamines in adipocytes. Catecholamines are hormones that bind to β-adrenergic receptors and act by increasing …
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LKB1 signaling pathways in adipocytes - Focus on the AMPK-related kinase SIK2
… adipocytes and describe a regulation of SIK2 and SIK3 by cAMP/PKA signaling. The PKA-dependent phosphorylations of SIK2 and SIK3 were identified and shown to mediate a binding to 14-3-3 proteins, resulting in a re-localization from a particulate fraction to the cytosol, and a decrease in activity, …
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Identification of novel protein kinase regulators of TGFβ signalling
… that genetic inactivation of SIK2 and SIK3 results in the attenuation of TGFβ-dependent transcriptional induction of the target gene PAI-1. Moreover, both PAI-1 transcript and protein expression are attenuated in cells which are deficient in the endogenous expression of LKB1, the …