Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 4 of 4 for “"SIK2"”.
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LKB1 signaling pathways in adipocytes - Focus on the AMPK-related kinase SIK2
… pathways in adipocytes, with a focus on SIK2, which is of particulate interest in adipocytes due to its high abundance in these cells. We show that AMPK activity is regulated by LKB1 and CaMKK in adipocytes and describe a regulation of SIK2 and SIK3 by cAMP/PKA signaling. The …
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SIK2 Inhibitor GRN-300 Enhances Sensitivity to Paclitaxel Treatment in Triple-Negative Breast Cancer
… therapies by targeting Salt-Inducible Kinase 2 (SIK2), which is overexpressed in 88% of TNBC specimens compared to normal breast tissue. We hypothesize that SIK2 inhibition could enhance paclitaxel efficacy and overcome resistance. In collaboration with Arrien Pharmaceuticals and Greenfire …
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The role of salt-inducible kinase in the control of hepatic gluconeogenesis
… members of the AMPK-related kinase family, the SIK2 isoform may play a role as signalling mediator in the control of insulin- and glucagon-regulated hepatic gluconeogenesis. However, the mechanisms of the hormonal-regulation of SIK2 in liver remain controversial, with much of the data based on …
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Identification of novel protein kinase regulators of TGFβ signalling
… I have demonstrated that genetic inactivation of SIK2 and SIK3 results in the attenuation of TGFβ-dependent transcriptional induction of the target gene PAI-1. Moreover, both PAI-1 transcript and protein expression are attenuated in cells which are deficient in the endogenous expression of LKB1, …