Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 51 for “"SHR"”.
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A Role for glutamate and Gaba in attention-deficit/hyperactivity disorder: a study of the spontaneously hypertensive rat
… of ADHD, the spontaneously hypertensive rat (SHR), compared to its control strain, the Wistar-Kyoto rat (WKY), and a third comparator strain, Sprague-Dawley rats (SD). Release of radio-actively labelled norepinephrine from hippocampal slices of SHR, WKY, and in some experiments SD, by …
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Understanding comorbid ADHD and cocaine abuse: consequences of adolescent medication in an animal model
… well-validated Spontaneously Hypertensive Rat (SHR) model of ADHD suggest that adolescent treatment with the stimulant methylphenidate increases cocaine abuse risk in adulthood, highlighting the need to identify alternative medications for teenagers with ADHD. Experiments 1-4 tested the …
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Alterations of central dopamine receptor sensitivity in the spontaneously hypertensive rat
… of the spontaneously hypertensive rat (SHR) into medical research, several neuropharmacological studies have been performed on these animals which have been unrelated to their cardiovascular systems. A few of these studies have indicated possible abnormalities in the dopaminergic systems …
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Pressor and depressor aspects of vasopressin in the spontaneously hypertensive rat
… of the spontaneously hypertensive rat (SHR) to AVP was tested by comparing the changes of BP, cardiac output (CO), and total peripheral conductance (TPC) to AVP in SHR to those in Wistar-Kyoto rats (WKY) both in the presence and absence of bosentan, a non-selective ET antagonist. …
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Effets centraux d'antagonistes non-peptidiques sélectifs pour les récepteurs AT1 ou AT2 de l'angiotensine II chez le rat hypertendu spontanément
… II (Ang) chez le rat hypertendu spontanément (SHR). Le PD123177, un composé sélectif pour les récepteurs AT2 de l'Ang, administré par voie intracérébroventriculaire (icv), n'affecte pas la pression artérielle (PA) du SHR. Deux antagonistes non-peptidiques sélectifs pour les récepteurs AT, …
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Myocardial force and intracellular Ca2+ in an animal model of hypertensive heart failure
… hearts of spontaneously hypertensive rats (SHR) and their normotensive Wistar-Kyoto (WKY) controls. At a physiological stimulation frequency (5 Hz), and temperature (37 °C), the peak stress of SHR trabeculae was significantly reduced compared to WKY, although no differences in the …
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Altered GABA ergic system in the posterior hypothalamus of the spontaneously hypertensive rat
… pressure in the spontaneously hypertensive rat (SHR), a useful animal model for studying human essential hypertension. The purpose of this thesis was to determine if the level of neuronal activity in the PH is augmented in the SHR compared to normotensive Wistar-Kyoto rats (WKY) and if so, is the …
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Characterization of Sympathetic Ganglion Sensitivity to Substance P in a Genetic and a Non-Genetic Rat Model of Hypertension.
… agonists in spontaneously hypertensive rats (SHR) in comparison to their normotensive counterparts, Wistar-Kyoto rats (WKY). Studies were also conducted to determine whether the increased ganglion responsiveness to SP in SHR is causally related to the increased BP or is a unique characteristic …
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Role of magnesium ions in the excitation of vascular smooth muscle. Effects of hypermagnesaemia and hypomagnesaemia on drug-induced contractions of mammalian arteries with special reference to the involvement of changed tissue calcium ion concentration or distribution in the observed responses.
… and spontaneously hypertensive rats (SHR). No differences in response to NA or ATP when extracellular [Mg 2+ ] was either increased or reduced were observed in the SHR compared to the normotensive animal. However, a difference in calcium dependence was demonstrated between the two …
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Effect of metformin treatment on isolated cardiac function and blood pressure in diabetic and hypertensive rats
… the Spontaneously hypertensive rat (SHR) and the fructose-induced hypertensive rat. SHR and their genetic normotensive controls, the Wistar-Kyoto (WKY) rat, were procured at 5 weeks (when hypertension is not manifest in the SHR). The rats were divided into four groups: SHR untreated, …
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In hypertension do smaller holes in arterial internal elastic lamina lead to fewer routes for myoendothelial junctions and hence less EDHF response?
… Normotensive (WKY) and hypertensive (SHR) rats of 12 weeks and 6 months of age were used to assess the effect of hypertension and ageing on endothelial and smooth muscle cell communication. The endothelium-derived hyperpolarising factor (EDHF) response in mesenteric arteries was …
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The tropical peatland carbon sink: climatic drivers and modelling of peat accumulation at the pan-tropical scale
… via soil heterotrophic respiration to CO2 (SHR-CO2) shows a sharp decrease under anoxic water-saturated conditions, with a mean ratio of SHR-CO2 under anoxic conditions and SHR-CO2 at the optimum moisture of 0.10 ± 0.08. The median value of Q10 for peat SHR-CO2 is 2.04. Model improvements …
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Posttraumatic Stress and Hazardous Alcohol Use in College Students: The Moderating Role of Alcohol Protective Behavioral Strategies
… subtypes (Al-PBS; Serious Harm Reduction [SHR], Manner of Drinking [MOD], Stopping/Limiting Drinking [SLD]) and gender on the relationships between traumatic stress symptoms and both hazardous drinking and alcohol-related negative consequences. Participants were 915 traditional age (18 to …
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Habitat overlap and seroprevalence of toxoplasma gondii in wildlife and feral cats in a natural area
… a large home range (LHR) or a small home range (SHR), based on published home range estimates and using a cutoff of 100 hectares. A total of 18 feral cats (16 at building and 2 at forest sites) were trapped with an overall seroprevalence of 33%; only one of the T. gondii positive cats was trapped …
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Effects of hypertension and aging on vascular smooth muscle cell contribution to reconstituted aortic tissue stiffness
… old male spontaneously hypertensive rats (SHR) and normotensive Wistar-Kyoto (WKY) rats were passaged four times and then separately incubated in collagen for two days on a cylindrical mandrel. The resulting tissue rings were subjected to repeated 10% strain steps. The ratio of the …
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Selenium and Functional State of the Vessel Wall under Normo- and Hypertension - Experimental Research // Селен и функционално състояние на съдовата стена при нормо- и хипертензия - експериментални проучвания
… (WKY) и спонтанно-хипертензивни плъхове (SHR). Експерименталните животни бяха разделени в групи, според породата и периода от живота им (пубертет и зряла възраст), през който в продължение на 8 седмици бяха приложени диети с различно съдържание на селен (Se) - ниско, препоръчително и …
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Magnesium Regulation of Calcium in Essential Hypertension
… hypertension, spontaneously hypertensive rats (SHR), and its control strain Wistar Kyoto (WKY) were used to investigate a possible environmental causal factor, cellular magnesium deficit, and its impact on the functional ability of the calcium ATPase. Rats were fed either a magnesium-deficient …
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Efeitos cronotropico e inotropico negativos induzidos pelo timol em ratos espontaneamente hipertensos
… and inotropic effects induced by thymol in the SHR rats , an essential model animal of hypertension as well as in their normot ensive control WKY , by system organ technique in isolated vitro using the atria isolated from these animals. In SHR , thymol induced negative chronotropic effects ( pD …
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Magnetic resonance imaging studies of cardiac changes in diabetic and hypertensive rats
… changes in the spontaneously hypertensive rats (SHR), also for the first time. The MRI studies of the diabetic heart were performed on male Wistar rats subdivided into four groups, each containing four animals. Diabetes was induced in three groups by single intraperitoneal streptozotocin …
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Renale Effekte von Angiotensin I und seinen Metaboliten bei experimenteller Hypertonie
… perfundierten Rattenniere in WKY-Ratten und SHR-SP zu untersuchen. Die Wirksamkeit auf die renale Druckantwort und stimulationsinduzierte Noradrenalinfreisetzung stellte sich wie folgt dar: Ang II ? Ang III > Ang I = des-Asp-Ang I >> Ang IV. Ang 1-7 induzierte per se keine Druckantwort sowie …
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