Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 26 for “"SHP2"”.
-
Shp2 Regulates Vascular Endothelial Matrix Degradation in Phosphatase-Independent Manner
Shp2 is a protein tyrosine phosphatase that is implicated in many diseases such as developmental disorders and cancers. One of its suggested physiological functions is regulation of angiogenesis, which is often impacted in Shp2 pathologies. However, its role in angiogenesis is still poorly …
-
The intramolecular domain interactions and phosphatase activation mechanisms of Shp2
Shp2 (Src Homology 2 Domain-containing Protein Tyrosine Phosphatase 2) is a pivotal player in various signaling pathways in response to growth factors. It contains two SH2 domains (N-SH2 and C-SH2), a phosphatase catalytic domain and a C-terminal tail containing two tyrosyl phosphorylation sites. …
-
Signalling mechanisms of the tyrosine phosphatase SHP2 upstream of Ras
… including cancer and developmental pathologies. SHP2 regulates multiple signalling cascades, including its crucial role in the complete activation of RasMAPK in KRas driven cancers. SHP2 is also the most commonly mutated protein in RASopathies such as Noonan syndrome. SHP2 is therefore an …
-
Modulation der IL-6-abhängigen Signaltransduktion durch die Protein-Tyrosinphosphatase SHP2
… containing protein-tyrosine-phosphatase 2 (SHP2), has been discovered, which seems to play an important role in the signaltransduction of many cytokines. The aim of this work was to elucidate the role of the tyrosine phosporylation of SHP2 in the IL-6 dependent signaltransduction via the …
-
Das Interaktom der SH2-Domänen der Proteintyrosinphosphatase SHP2 und ihren krankheitsrelevanten Mutanten
The protein tyrosine phosphatase SHP2 is a common regulator of cytokine, growth factor signaling and has been shown to influence cell survival, proliferation and differentiation by regulation of MAP Kinase, Jak/STAT and PI3K pathways. Structurally SHP2 consists of two SH2 domains, a catalytically …
-
Effects of mutant SHP2 expression on heart function in Duchenne muscular dystrophy
… SH2 domain-containing tyrosine phosphatase 2 (SHP2) plays a regulatory role in several cell signaling events. Work from our lab has discovered that a loss-offunction mutation in SHP2 improves heart function after transverse aortic banding. I hypothesized that expression of a loss-of-function …
-
Targeting the protein tyrosine phosphatase, SHP2, and PI3K in FLT3-ITD+ leukemia
… myeloid leukemia (AML). We hypothesized that Shp2 interacts with FLT3-ITD via protein complexes at tyrosine (Y) 768, 955, and/or 969 and that Shp2 and PI3K work cooperatively to promote FLT3-ITD-induced leukemogenesis. Consistently, mutation of N51-FLT3 tyrosine 768 to phenylalanine reduced …
-
Exploring the mechanism of SHP2 and EGFR/HER2 cooperation in breast cancer cell signaling
… 2-containing protein tyrosine phosphatase 2 (SHP2) has been established as a critical mediator of cancer-related cell signaling downstream of receptor tyrosine kinases like EGFR and HER2. As such, targeting of SHP2 is being recognized as a potentially viable therapeutic option in HER2-positive …
-
Bedeutung der IL-6-Signaltransduktionsinhibitoren SHP2 und SOCS3 für die Desensitisierung des IL-6-Signalweges
… 2 (SH2)-containing protein tyrosine phosphatase SHP2 and the feedback inhibitor SOCS3 (suppressor of cytokine signalling) are potent inhibitors of IL-6 signal transduction. Impaired function of SOCS3 or SHP2 leads to enhanced and prolonged IL-6 signalling. The inhibitory function of both proteins …
-
Funktion der Protein-Tyrosin-Phosphatase SHP2 und des feedback-Inhibitors SOCS3 in der IL-6-Signaltransduktion
… site for the protein tyroinse phosphatase SHP2 and for the STAT induced feedback inhibitor SOCS3. Therefore the relative contributions of SHP2 and SOCS3 to the repression of the IL-6 signal transduction were investigated. In this work it could be shown that SHP2 inhibits the Jak/STAT …
-
Funktionelle Untersuchungen zum PTPN11-Genprodukt SHP2 und zu PTPN11 Mutanten, die dem Noonan-Syndrom zugrunde liegen
… die Nichtrezeptor Protein-Tyrosin-Phosphatase SHP2, die zwei Src-homology-2 (SH2) Domänen und eine Phosphatase-Domäne besitzt. Die N-terminale SH2-Domäne (N-SH2) ist ein konformativer Schalter: entweder interagiert N-SH2 mit der Phosphatase-Domäne (PTP) und hemmt diese, oder sie bindet an ein …
-
Funktion der Protein-Tyrosin-Phosphatase SHP2 bei der Interleukin 6 vermittelten Akutphase - Genregulation und T-Zell-Migration
… The protein tyrosine phosphatase SHP2 (SH2 - containing tyrosine phosphatase) is recruited to gp130, the signaltransducing subunit of the IL-6R-Komplex, und is an adaptor for the Ras/Raf/MAPK-cascade. Here it could be demonstrated, that SHP2 inhibits STAT-dependent gene induction, …
-
Das Tyrosin 759 des Signaltransduktors gp130 in der IL-6-abhängigen Proliferation von Prä-B-Zellen
… STAT1, STAT3, the protein tyrosine phosphatase SHP2 and the feedback inhibitor SOCS3. SHP2 tyrosine phosphorylation is crucial for the activation of the Ras/Raf/MAPK pathway and thus proliferation and differentiation after IL-6 stimulation. Furthermore SHP2 is involved in negative regulation of …
-
Repression der IL-6-Signaltransduktion über das zytoplasmatische Tyrosin 759 des Signaltransduktors gp130
… and demonstrate that the tyrosine phosphatase SHP2 and SOCS3 do not act independently, but are functionally linked. Furthermore, we show that tyrosine 759 in gp130 is essential for both SHP2 and SOCS3, but not for SOCS1 to exert their inhibitory activities on interleukin-6 signal transduction. …
-
Regulation of IL-6 signal transduction, contributions of the Signal Regulatory Protein (SIRP) and cyclic AMP
… alpha binds to the protein tyrosine phosphatase SHP2 upon IL-6 stimulation. Mouse embryonal fibroblasts which express a SIRP alpha protein lacking the intracellular part show an enhanced SHP2 phosphorylation and ERK1/2 activation in response to IL-6, suggesting that SIRP alpha affects …
-
Reiterative FGF signaling determines the identity and morphology of the lacrimal gland
… FGF signaling mediated by protein phosphatase Shp2 is required for the proper patterning and differentiation of the neural crest-derived mesenchyme to produce Fgf10. Genetic evidence further demonstrates that Shp2 is recruited by Frs2α to activate Ras-MAPK signaling downstream to Fgfr1 and …
-
Das Adapterprotein Gab1 in der Regulation der IL-6 Signaltransduktion
… detail. It turned out that Gab1 interaction with SHP2 and Grb2 is required for the ERK-activation after IL-6 stimulation. Additionally, Gab1 has to bind with its PH-domain to the phospholipid PtdIns(3,4,5)P3 to activate the MAPK-cascade. The interactions with SHP2, Grb2 and PtdIns(3,4,5)P3 are …
-
Interrogating therapeutic resistance to oncogenic KRASG12C-based therapies in colorectal cancer
… progressing patients. We examine the role of SHP2 as a mechanism of adaptive resistance and investigate the efficacy of a KRASG12C and SHP2 inhibitor combination in our in vivo models. We show that this combination has better efficacy than the well-established KRASG12C and EGFR inhibitor …
-
SALICYLALDEHYDE-TAGGED PEPTIDES FOR THE REVERSIBLE-COVALENT ENGAGEMENT OF PROTEIN LYSINE RESIDUES
… specific for two protein targets, namely SHP2 and NEMO. Moreover, using human serum albumin as model target, the CuAAC protocol was instrumental for the design of a new combinatorial approach to SA-tagged small molecules. The final part of the work, carried out at the University of Tokyo, …
Page 1 of 2