Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 5 of 5 for “"SHP1"”.
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Responses to Tumour initiating factors and Regulation of Normal and Malignant Haematopoiesis
… VEGFR-1 and VEGFR-2 as well as PTEN and SHP1 in childhood ALL using immunohistochemistry. We observed that the expression of VEGFR-1, PTEN and SHP1 in mononuclear cells of children with ALL were significantly different to the expression of mononuclear cells in children with no malignant …
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Studies on the Leukocyte-Associated Ig-Like Inhibitory Receptor-1 Signaling Pathway in T Lymphocytes
… LAIR-1 and its ligand interaction, and whether SHP1 plays a role in LAIR-1 signaling and T cell activation.</p> <p>I validated previous findings that suggested LAIR-1 stimulation by its natural ligand collagen suppresses T cell antigen receptor (TCR)-mediated T-cell activation. To study proximal …
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Crosstalk Between R1175 Methylation and Y1173 Phosphorylation Negatively Modulates Egfr-Mediated Erk Activation
… This novel modification crosstalk increases SHP1 recruitment to EGFR and suppresses EGFR-mediated ERK activation, resulting in inhibition of cell proliferation, migration, and invasion of EGFR-expressing cells. Based on these findings, we provide the first link between arginine methylation …
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Molecular analysis of vesicle biogenesis during autophagy
… Cdc48 and its major substrate-recruiting factor Shp1 for efficient PMN Summary 2 as well as macroautophagy. The human homologues of Cdc48 / Shp1 p97 / p47 are involved in human mitotic Golgi reassembly. This p97 / p47 complex is thought to extract a monoubiquitylated fusion inhibitor out of …
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CD148: a positive regulator of GPVI and \(\alpha\)II\(\beta\)3 proximal signalling in platelets
… six non-transmembrane PTPs (NTPTPs), PTP-1B, Shp1, Shp2, MEG2-PTP, LMW-PTP and HePTP and a single receptor-like PTP (RPTP), CD148, have been identified in platelets. The main objective of this thesis was to determine the functional role of CD148 in platelets, which had never been studied in …