Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 14 of 14 for “"SHP-2"”.
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Regulation of cell motility by Shp-2 tyrosine phosphatase
This document only includes an excerpt of the corresponding thesis or dissertation. To request a digital scan of the full text, please contact the Ruth Lilly Medical Library's Interlibrary Loan Department (rlmlill@iu.edu).
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The Regulation of Src Homology 2 Domain-Containing Protein Tyrosine Phosphatase 2 (SHP-2) in Brain Microglia
SHP-2, a member of protein tyrosine phosphatases (PTPs), plays a role on the regulation of several signaling pathway such as NF-kB, MAP kinase, JAK-STAT, and PI3 kinase. However, the roles of SHP-2 in brain microglia activation are largely unknown. Here, I determined the regulation of SHP-2 on …
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Rôles de la protéine tyrosine phosphatase SHP-2 dans l'inflammation intestinale et le cancer colorectal associé à la colite
SHP-2 est une tyrosine phosphatase impliquée dans la signalisation intracellulaire déclenchée par des facteurs de croissance, des cytokines pro-inflammatoires et des produits bactériens. Bien que cette phosphatase soit exprimée de manière ubiquiste et donc dans l’épithélium intestinal, son rôle …
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Regulation of Syk activity in GPVI-mediated platelet activation
… published reports implicate the phosphatases SHP-1, SHP-2 and TULA-2 in the negative regulation of Syk. Therefore, we tested these phosphatases possible role in platelets. We show that SHP-1 can dephosphorylate Syk in vitro, but is unable to bind Syk. Also, Syk is hypophosphorylated in …
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Regulation of STAT-3 and STAT-6 by Transient Oxidative Stress in Rat Brain Astrocytes
… steady state level of STAT-3 phosphorylation by SHP-2 activation through lipid raft. In the presence of H2O2, SHP-2 formed a complex with STAT-3, and reduced the steady-state STAT-3 phosphorylation level. H2O2 triggered SHP-2 phosphorylation in a time- and dose-dependent manner, and led to its …
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Studies on the Leukocyte-Associated Ig-Like Inhibitory Receptor-1 Signaling Pathway in T Lymphocytes
… contains SH2 domain-containing phosphatase (SHP)-1, SHP-2, C-terminal src kinase (Csk), and/or the protein tyrosine phosphatase, non-receptor 22 (PTPN22), whether these phosphatases are activated upon LAIR-1 and its ligand interaction, and whether SHP1 plays a role in LAIR-1 signaling and T …
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Ligand-induced selective signalling at the gonadotrophin releasing hormone receptor
… partner, the SH2 domaincontaining phosphatase 2 (SHP-2). I propose that SHP-2 mediates the antiproliferative effects of the receptor. I show that the SHP-2 pathway is activated independently of Gq/11 and suggest that signalling occurs by a direct interaction of SHP-2 and src with the GnRH …
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Molecular Mechanisms Regulating Fate Determination of Cerebral Cortex Precursors
… of this thesis, the protein tyrosine phosphatase SHP-2 was identified as a novel signaling protein that regulates the neurogenic to gliogenic switch by potentiating neurogenic signals and suppressing gliogenic signals until the appropriate developmental time point for astrogenesis, providing one …
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Specificity of SH2 domains and protein tyrosine phosphatases
… In the first part, the SH2 domains of the PTP SHP-2 were characterized. The specificity of these SH2 domains was shown to involve two residues N-terminal to the target pY in addition to three C-terminal residues. A single residue of the SH2 domains was found to play a critical role in directing …
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Eine neue Domäne der IL-6 Rezeptor β -Kette, gp130, vermittelt Zellwachstum und die Aktivierung der Kinasen Hck und Erk
… von den benachbarten Bindungsstel-len für Shp-2 (Y759) und STAT3 (Y767, Y814). In faktor-abhängig wachsenden Baf-B03 Zellen resultierte die Deletion der Hck-Bindungsdomäne (d 771-811) in einem deutlich reduzierten Wachstum nach Stimulation von gp130. Die Aktivität der Src-Kinase Hck war in …
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Mesothelial and Mural Cell Contribution to Vascular Development through PDGF Signaling
… includes PI3 kinase, Src, RasGAP, Grb2, Shp-2, and PLC?gamma for the regulation of cellular functions.The focus of this research was to determine the temporal and functional requirements of PDGFR signaling in mural cells. To address the temporal requirements for PDGFR beta, genetic …
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Design and Development of a Novel Immunological Method to Quantify target-specific cysteine redox state in a microplate
… 2 domain-containing protein Tyr phosphatase 1 (SHP-<br/>1), cluster of differentiation 45 (CD45) and the cα subunit of protein phosphatase<br/>2A (PP2A) -specific thiol oxidation, without altering the thiol oxidation of Src<br/>homology 2 domain-containing protein Tyr phosphatase 2 (SHP-2), …
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REDOX REGULATION OF B CELL ACTIVATION AND THE ANTI-VIRAL HUMORAL IMMUNE RESPONSE
… revealed that the protein tyrosine phosphatases SHP-1, SHP-2, and PTEN were modified to cysteine sulfenic acid following B cell activation. Using 5,5-dimethyl-1,3-cyclohexanedione (dimedone), a compound that covalently reacts with sulfenic acid to prevent its further oxidation or reduction, we …
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Redox Regulation of T cell Activation and Function During Viral Infection
… revealed that the protein tyrosine phosphatases SHP-1 and SHP-2, as well as actin, underwent increased sulfenic acid modification following stimulation. To examine the contribution of reversible cysteine sulfenic acid formation to T cell activation increasing concentrations of 5, 5 …