Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 13 of 13 for “"SHP-1"”.
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DJ-1, a Parkinson’s Disease-associated Gene, Prevent Excessive Glial Inflammatory Responses through Interaction with SHP-1
… interaction between STAT1 and its phosphatase, SHP-1 (Src-homology 2-domain containing protein tyrosine phosphatase-1). Astrocytes and microglia cultured from DJ-1-knockout (KO) mice exhibited increased expression of inflammatory mediators and phosphorylation levels of STAT1 (p-STAT1) in …
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Délétion endothéliale de SHP-1 prévient la sénescence et rétablit l’angiogenèse des cellules endothéliales vasculaires en condition de diabète
… expression of protein tyrosine phosphatase SHP-1 in the ischemic muscle of diabetic mice was associated with higher phosphatase activity in the endothelial cells (EC) exposed to high concentrations of glucose. Our objective was to evaluate the role of SHP-1 in the regulation of the …
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Studies on the Leukocyte-Associated Ig-Like Inhibitory Receptor-1 Signaling Pathway in T Lymphocytes
… contains SH2 domain-containing phosphatase (SHP)-1, SHP-2, C-terminal src kinase (Csk), and/or the protein tyrosine phosphatase, non-receptor 22 (PTPN22), whether these phosphatases are activated upon LAIR-1 and its ligand interaction, and whether SHP1 plays a role in LAIR-1 signaling and T …
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Regulation of Syk activity in GPVI-mediated platelet activation
… published reports implicate the phosphatases SHP-1, SHP-2 and TULA-2 in the negative regulation of Syk. Therefore, we tested these phosphatases possible role in platelets. We show that SHP-1 can dephosphorylate Syk in vitro, but is unable to bind Syk. Also, Syk is hypophosphorylated in …
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Der inhibitorische Einfluss von CD22 auf das B-Zellrezeptorsignal nach Stimulation der B-Zelle
… BZR-Ligation lagert sich die Tyrosin-Phosphatase SHP-1 an die cytoplasmatische Domäne von CD22 an, wodurch SHP-1 aktiviert wird. Durch die dephosphorylierende Aktivität der Phosphatase moduliert sie das BZR-Signal. Zum anderen ist CD22 ein Adhäsionsmolekül, das in die Gruppe der Siglecs (Sialic …
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A candidate gene based investigation of aberrant DNA methylation in the pathogenesis of primary cutaneous T-cell lymphoma
… of DNA methylation to the regulation of SHP-1, Fas and PLS3, which have been implicated in the pathogenesis of CTCL, was examined. Gene expression was assessed on the mRNA and protein levels using qPCR and flow cytometry re¬spectively whilst DNA methylation was evaluated using bisulphite …
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Generierung von chimären Mäusen mit Mutationen in der Signalleitungs-Domäne von CD22 und Untersuchungen zur Funktion von CD22 in Knockout-Mäusen
… Die cytosolische Tyrosin-Phosphatase SHP-1 bindet in der Folge an die phosphorylierten ITIMs, wird aktiviert, und inhibiert das BCR Ca2+-Signal. Gleichzeitig binden jedoch auch positive Modulatoren des BCR-Signals (Lyn, Syk, PLCg PI3K, und Grb-2) an CD22, deren Rolle im Zusammenhang …
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CD40 stimulation activates ‘post-activated’ B Cells which are hyporesponsive to B Cell receptor and toll-like receptor 9 stimulation in autoimmunity
… region 2 (SH2) domain-containing phosphatase-1 (SHP-1). The relevance of cytokines, epigenetic methylation and chronic stimulation of TLR9 and the BCR was assessed. The potential of TLR9 and TLR9 together with BCR activation to induce proliferation and differentiation into antibody secreting …
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Inactivation of the JAK-STAT Pathway
… proteasome, induced inhibitory proteins and the SHP-1 protein tyrosine phosphatase were all shown to play a role in the inactivation of the IFN-γ receptor-JAK complex but not in the direct inactivation of Stat1 molecules. By analyzing the flow of phosphorylated Stat1 from cytoplasm to nucleus and …
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REDOX REGULATION OF B CELL ACTIVATION AND THE ANTI-VIRAL HUMORAL IMMUNE RESPONSE
… revealed that the protein tyrosine phosphatases SHP-1, SHP-2, and PTEN were modified to cysteine sulfenic acid following B cell activation. Using 5,5-dimethyl-1,3-cyclohexanedione (dimedone), a compound that covalently reacts with sulfenic acid to prevent its further oxidation or reduction, we …
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Molekularbiologische und funktionelle Charakterisierung neuer "Chicken Ig-like" Rezeptoren
… and recruited the protein-tyrosine- phosphatases SHP-1 and -2. Additionally ligation of CHIR-B2 had an inhibitory effect on the cell proliferation of a B-cell line. The potentially inhibitory and activating CHIR-AB had one Ig-domain, a long cytoplasmic tail with one ITIM in it and a positively …
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Redox Regulation of T cell Activation and Function During Viral Infection
… revealed that the protein tyrosine phosphatases SHP-1 and SHP-2, as well as actin, underwent increased sulfenic acid modification following stimulation. To examine the contribution of reversible cysteine sulfenic acid formation to T cell activation increasing concentrations of 5, 5 …
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Verwendung von Gene-Targeting-Techniken zur Etablierung neuer Mauslinien mit Mutationen in B-Zell-Signalwegen
… die inhibitorische Tyrosinphosphatase SHP-1 gebunden, aktiviert, und ist nun in der Lage das BCR Ca2+ Signal zu inhibieren. Um die Rolle der CD22Ligandenbindungsdomäne, in vivo zu untersuchen, sollte in dieser Arbeit eine CD22 knock -in Maus erzeugt werden (CD22R130E Maus), in der die …