Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 50 for “"SHP"”.
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Regulation of cell motility by Shp-2 tyrosine phosphatase
This document only includes an excerpt of the corresponding thesis or dissertation. To request a digital scan of the full text, please contact the Ruth Lilly Medical Library's Interlibrary Loan Department (rlmlill@iu.edu).
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Elucidating the role of small heterodimer partner (SHP) in metabolism, injury and systemic disease
Submission published under a 24 month embargo labeled 'U of I Access', the embargo will last until 2026-12-01
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Uncovering a novel role for FXR-SHP axis in liver physiology, diseases and beyond
… the role of two nuclear receptors, FXR and SHP in maintaining liver function. Farnesoid X Receptor (FXR) and Small Heterodimer Partner (SHP) are well-known regulators of glucose, fat and bile acid homeostasis. Here, I uncover novel roles for FXR-SHP axis not only in the liver but also in …
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Multicriteria Decision Method for Renewable Energy Production: Siting Solar, Wind and SHP Plants in Zimbabwe
… has enormous potential for wind, solar, and SHP resources, all of which have the potential to alleviate the country's severe energy shortages. Hwange Rural, which has a land area of 26 974 km2, is the best place for solar power plants. The Beitbridge Rural District, which has a land area of …
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The roles of orphan nuclear receptors, SHP and FXR, and their cofactors in bile acid signaling
… X receptor (FXR) and small heterodimer partner (SHP), have been identified as key regulators in bile acid signaling. FXR was revealed as the first in vivo bile acid biosensor and was shown to regulate cholesterol/bile acid homeostasis by suppressing the transcription of cholesterol 7-a …
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DJ-1, a Parkinson’s Disease-associated Gene, Prevent Excessive Glial Inflammatory Responses through Interaction with SHP-1
… interaction between STAT1 and its phosphatase, SHP-1 (Src-homology 2-domain containing protein tyrosine phosphatase-1). Astrocytes and microglia cultured from DJ-1-knockout (KO) mice exhibited increased expression of inflammatory mediators and phosphorylation levels of STAT1 (p-STAT1) in …
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The Regulation of Src Homology 2 Domain-Containing Protein Tyrosine Phosphatase 2 (SHP-2) in Brain Microglia
SHP-2, a member of protein tyrosine phosphatases (PTPs), plays a role on the regulation of several signaling pathway such as NF-kB, MAP kinase, JAK-STAT, and PI3 kinase. However, the roles of SHP-2 in brain microglia activation are largely unknown. Here, I determined the regulation of SHP-2 on …
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Regulation of Bile Acid Biosynthesis by Orphan Nuclear Receptor Small Heterodimer Partner
… how bile acid biosynthesis is regulated in both SHP-dependent and SHP-independent pathways. Importantly, these studies for the first time demonstrate that SHP has a short half-life of 20 to 30 minutes. Bile acids and FGF15/19 signaling pathways, and SHP ligand can dramatically increase SHP …
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Modulation of the activity of a key metabolic regulator Small Heterodimer Partner by post-translational modifications
Small Heterodimer Partner (SHP, NR0B2), a member of the nuclear receptor superfamily, is an orphan receptor that lacks a DNA binding domain but contains a putative ligand binding domain. SHP forms non-functional heterodimers with DNA binding transcriptional factors and, thereby, functions as a …
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Studies on the Leukocyte-Associated Ig-Like Inhibitory Receptor-1 Signaling Pathway in T Lymphocytes
… contains SH2 domain-containing phosphatase (SHP)-1, SHP-2, C-terminal src kinase (Csk), and/or the protein tyrosine phosphatase, non-receptor 22 (PTPN22), whether these phosphatases are activated upon LAIR-1 and its ligand interaction, and whether SHP1 plays a role in LAIR-1 signaling and T …
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Délétion endothéliale de SHP-1 prévient la sénescence et rétablit l’angiogenèse des cellules endothéliales vasculaires en condition de diabète
… expression of protein tyrosine phosphatase SHP-1 in the ischemic muscle of diabetic mice was associated with higher phosphatase activity in the endothelial cells (EC) exposed to high concentrations of glucose. Our objective was to evaluate the role of SHP-1 in the regulation of the …
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Rôles de la protéine tyrosine phosphatase SHP-2 dans l'inflammation intestinale et le cancer colorectal associé à la colite
SHP-2 est une tyrosine phosphatase impliquée dans la signalisation intracellulaire déclenchée par des facteurs de croissance, des cytokines pro-inflammatoires et des produits bactériens. Bien que cette phosphatase soit exprimée de manière ubiquiste et donc dans l’épithélium intestinal, son rôle …
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Regulation of Syk activity in GPVI-mediated platelet activation
… published reports implicate the phosphatases SHP-1, SHP-2 and TULA-2 in the negative regulation of Syk. Therefore, we tested these phosphatases possible role in platelets. We show that SHP-1 can dephosphorylate Syk in vitro, but is unable to bind Syk. Also, Syk is hypophosphorylated in …
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The role of microRNA-802 regulated by the nuclear receptor FXR-SHP cascade in obesity and non-alcoholic fatty liver disease
Submission published under a 24 month embargo labeled 'U of I Access', the embargo will last until 2024-12-01
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Regulation of STAT-3 and STAT-6 by Transient Oxidative Stress in Rat Brain Astrocytes
… steady state level of STAT-3 phosphorylation by SHP-2 activation through lipid raft. In the presence of H2O2, SHP-2 formed a complex with STAT-3, and reduced the steady-state STAT-3 phosphorylation level. H2O2 triggered SHP-2 phosphorylation in a time- and dose-dependent manner, and led to its …
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Phenobarbital Induced Transcriptional Activation of CYP2B Genes by Chromatin Modification at the PBRU Region
… transactivation by short heterodimer receptor (SHP) was examined and, second, the effect PB treatment on nucleosomal position and structure in native chromatin was examined. SHP did not affect the binding of CAR/RXR to the PBRU or the recruitment of the coactivator GRIP 1 by CAR/RXR in vitro. …
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Ligand-induced selective signalling at the gonadotrophin releasing hormone receptor
… partner, the SH2 domaincontaining phosphatase 2 (SHP-2). I propose that SHP-2 mediates the antiproliferative effects of the receptor. I show that the SHP-2 pathway is activated independently of Gq/11 and suggest that signalling occurs by a direct interaction of SHP-2 and src with the GnRH …
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Der inhibitorische Einfluss von CD22 auf das B-Zellrezeptorsignal nach Stimulation der B-Zelle
… BZR-Ligation lagert sich die Tyrosin-Phosphatase SHP-1 an die cytoplasmatische Domäne von CD22 an, wodurch SHP-1 aktiviert wird. Durch die dephosphorylierende Aktivität der Phosphatase moduliert sie das BZR-Signal. Zum anderen ist CD22 ein Adhäsionsmolekül, das in die Gruppe der Siglecs (Sialic …
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Elucidating the Molecular Mechanisms Underlying the Hepatic Farnesoid X Receptor (FXR)-mediated Effects that Contribute to the Triglyceride-Lowering Ability of a Grape Seed Proceyanidin Extract
… thereby increasing small heterodimer partner (SHP) messenger ribonucleic acid (mRNA) expression, which then inhibits transcription of Sterol Regulatory Element Binding Protein 1c (SREBP-1c), a key transcription factor regulating lipogenic gene expression. The objective of this study is to …
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Development of a Framework for Sustainable Social Housing Provision (SSHP) in England
Sustainable social housing provision (SSHP) has become very important over the last few decades for the main objective of meeting housing needs. Despite this, there is evidence to suggest that SSHP has not been practiced successfully. A growing body of the literature shows that lack of an …
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