Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 15 of 15 for “"SHIV"”.
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An Investigation of the SHIV reservoirs in the lymphoid organs of HIV-vaccinated rhesus monkeys after SHIV challenge
… key time points pre- and post- vaccination and SHIV challenge were used to measure the levels of HIV Env and SIV Gag antibodies by Western blotting, and HIV-1 Env gp140 ELISA. RNA viral loads were low for all animals with the median of the averages of the viral load for PBMCs being 3.82 …
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Development And Validation Of Novel Transmitted/founder Shivs For Hiv-1 Persistence And Cure Research
A robust simian-human immunodeficiency virus (SHIV)-rhesus macaque (RM) model of HIV latency and cure is needed. Our group has generated >20 SHIVs encoding various HIV-1 Envs of interest, including transmitted/founder (TF) Envs. TF SHIVs encode a substitution at Env residue 375 that confers …
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Developing improved challenge viruses for macaque models of HIV-1 infection
… of macaques with SIV/HIV chimeric viruses (SHIVs) is often used as a model of HIV-1 infection for pre-clinical vaccine studies. Although SHIV infection of macaques serves as the gatekeeper of promising vaccine candidates, it is limited by the fact there are a very small number of SHIVs …
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Deep Learning in Oesophageal Cancer Development: Integrating Multi-Stain Histopathology Images of the Capsule Sponge
… model, however, performed poorly. Finally, Shiv Sakthivel and I developed an interpretable algorithm that detects atypia based on glandular and nuclear features already used in pathology practice. Together, these methods establish a scalable, efficient, and clinically applicable framework …
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The Role of Mucosal Epithelial Cells In Hiv-1 Infection
… or with the simian-human immunodeficiency virus (SHIV) by the vaginal, oral or rectal route exhibited dramatic increases in: TSLP expression, DC and CD4+ T cell numbers, and viral replication, in the vaginal, oral, and rectal tissues, respectively within the first 2 weeks after virus exposure. …
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An experimental comparison of partitioning strategies in distributed graph processing
In this thesis, we study the problem of choosing among partitioning strategies in distributed graph processing systems. To this end, we evaluate and characterize both the performance and resource usage of different partitioning strategies under various popular distributed graph processing systems, …
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On single-cell immune dynamics of chronic HIV infection and treatment in rhesus macaque models
… with Simian Human Immunodeficiency Virus (SHIV). Here I identify features of therapeutic response and implicate a previously defined Antibody-Dependent Cellular Phagocytosis signature as being associated with control. Furthermore, I identify a new cytotoxic transcriptional module in T and …
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Perspective Transformer for the Stereomatrix Three-Dimensional Display-System
Made available in DSpace on 2014-12-10T19:07:10Z (GMT). No. of bitstreams: 1 7317458.pdf: 2442986 bytes, checksum: aae96b531294240949adc4ad4922e9ce (MD5) Previous issue date: 1972
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How Oomycete and Fungal Effectors Enter Host Cells and Promote Infection
The genus Phytophthora contains a large number of species that are known plant pathogens of a variety of important crops. Phytophthora sojae, a hemibiotroph, causes approximately 1-2 billion dollars (US) of lost soybean world-wide each year. P. infestans, the causative agent of the Irish potato …
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Human Movement Analysis: Ballistic Dynamics, and Edge Continuity for Pose Estimation
We present two contributions to human movement analysis: (a) a ballistic dynamical model for recognizing movements, and (b) a model for coupling edge continuity with contour matching. We describe a Bayesian approach for visual analysis of ballistic hand movements, namely reaches and strikes. These …
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Methods in Total Synthesis: Development of a 2nd-Generation Synthesis of CJF-III-288, and Synthetic Efforts Towards the Total Synthesis of Sequoiamonascin A
… potency and protected monkeys from intrarectal SHIV challenge. However, the activity of BNM-III-170 was not sufficient for clinical use and some primary HIV-1 strains were completely resistant, so the need arose to develop new CD4mcs that inhibited a broader range of HIV strains with enhanced …
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Electrochemical Treatment of Tumors (EChT)
Electrochemical treatment of cancerous tumors is a minimally invasive, versatile and relatively safe technology in which the direct electric current is changed to destructive reaction products by electrochemical reactions at electrode surfaces. It is believed that extreme cathodic and anodic pH …