Global ETD Search
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Showing 1 to 6 of 6 for “"SHIP2"”.
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The 5' inositol phosphatase SHIP2 regulates EGF-elicited protrusion in MTLn3 cells
… SH2- domain containing 5-inositol phosphatase (SHIP2) interacts with Mena and is thought to play a role in breast cancer. SHIP2 is a 5-phosphatase that catalyzes the dephosphorylation of phosphatidylinositol 3,4,5-trisphosphate (PI(3,4,5)P 3) to phosphatidylinositol 3,4-bisphosphate (PI(3,4)P2) …
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Src Homology 2 Domain-Containing 5’-Inositol Phosphatase-2 (Ship2) Is An Effector of Lymphatic Dysfunction
… 2-domain containing 5’-inositol phosphatase-2 (SHIP2), encoded by <em>INPPL1</em>, are associated with lymphatic abnormalities. SHIP2 is a phosphatidyIinositol (3,4,5) triphosphate (PIP3) 5’-phosphatase that negatively controls PIP3 levels thereby inhibiting the PI3K/AKT signaling, a pathway …
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Synthesis, Design, and Biological Evaluation of Inhibitors and Activators of Src Homology 2 Domain-Containing Inositol Phosphatase (SHIP) and Synthetic Studies of Apicularen A and Maoecrystal V
… with 3AC, many showed significant inhibition of SHIP2, suggesting that not all aminosteroids are SHIP1 selective inhibitors. Some known SHIP1 activators were also pursued, as these molecules would be useful for validation of screening techniques and biological assays. The reported structure …
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Synthetic Studies on Small Molecule Modulators of Src Homology 2 (SH2) Domain-Containing Inositol 5’-Phosphatase (SHIP)
… (primarily expressed in hematopoietic cells) and SHIP2 (expressed across all cell types).</p> <p>SHIP1 has also been recognized to be an allosterically activated enzyme, with several small molecule agonists having been reported in the literature. These studies have culminated in the identification …
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Novel Insights into the Regulation and Function of SGK3
… sequential dephosphorylation of PI(3,4,5)P3 by SHIP2 and INPP4A/B phosphatases. These highly versatile mechanisms of SGK3 regulation explain how the Vps34-SGK3 axis is able to substitute for Akt following inhibition of PI3K Class I/Akt pathways. They also illustrate robustness of SGK3 activity …
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The role of PTEN as a PI(3,4)P2 lipid phosphatase in Class I phosphoinositide 3-kinase signalling
Name: Anna Jadwiga Kielkowska Dissertation title: The role of PTEN as a PI(3,4)P2 lipid phosphatase in Class I phosphoinositide 3-kinase signalling Abstract Class I phosphoinositide 3-kinases (Class I PI3Ks) are essential players involved in the signalling events in the cell and are critical …