"SHIP inhibitors" · 5 results · Global ETD Search

CONVENIENT ETHERIFICATION USING TRICHLOROACETIMIDATES AND SYNTHESIS OF AMINOSTEROID SHIP INHIBITORS

Howard, Kyle Timothy

… by the kinase PI3K and the phosphatases PTEN and SHIP.</p> <p>SHIP1 is an SH2-containing inositol 5’-phosphatase found in blood cells that is responsible for the hydrolysis of phosphatidylinositol-3,4,5-trisphosphate to phosphatidylinositol-4,5-bisphosphate. This enzyme is part of a major cellular …

syracuse-diss Repository record for CONVENIENT ETHERIFICATION USING TRICHLOROACETIMIDATES AND SYNTHESIS OF AMINOSTEROID SHIP INHIBITORS (opens in a new tab)

A Modular Approach to Highly Functionalized Indole Derivatives and Syntheses of Tryptamine-based SHIP Inhibitors

Shah, Jigisha

… with their analogs, are recognized as potent SHIP inhibitors and are considered privileged structures due their binding properties and diverse biological targeting. Also, the pyrrolo[2,3-a]indoline frameworks have been recognized as key structural motifs in many anticancer and psychoactive …

syracuse-diss Repository record for A Modular Approach to Highly Functionalized Indole Derivatives and Syntheses of Tryptamine-based SHIP Inhibitors (opens in a new tab)

Trichloroacetimidates as Alkylating Reagents in C-N Bond Formation and Synthesis of Aminosteroid and Quinoline Inhibitors of Src Homology 2 Domain-Containing Inositol Phosphatase (SHIP)

Wallach, Daniel Ryan

… of the SH2-containing inositol 5’-phosphatase (SHIP) can modulate the dephosphorylation of phosphoinositols. These molecules act as second messengers in a signal transduction cascade, with the placement of phosphorylation on the inositol acting to convey information in the transmission of …

syracuse-diss Repository record for Trichloroacetimidates as Alkylating Reagents in C-N Bond Formation and Synthesis of Aminosteroid and Quinoline Inhibitors of Src Homology 2 Domain-Containing Inositol Phosphatase (SHIP) (opens in a new tab)

Trichloroacetimidates as Alkylating Reagents and Their Application in the Synthesis of Pyrroloindoline Natural Products and Synthesis of Small Molecule Inhibitors of Src Homology 2 Domain- Containing Inositol Phosphatase (SHIP)

Adhikari, Arijit Anand

… to the above work, synthesis of small molecule inhibitors of Src Homology 2 Domain-Containing Inositol Phosphatase (SHIP) has also been described. Aberrations in the phosphoinositide 3-kinase (PI3K) cellular signaling pathway can lead to diseased cellular states like cancer. Herein we have …

syracuse-diss Repository record for Trichloroacetimidates as Alkylating Reagents and Their Application in the Synthesis of Pyrroloindoline Natural Products and Synthesis of Small Molecule Inhibitors of Src Homology 2 Domain- Containing Inositol Phosphatase (SHIP) (opens in a new tab)

Synthesis, Design, and Biological Evaluation of Inhibitors and Activators of Src Homology 2 Domain-Containing Inositol Phosphatase (SHIP) and Synthetic Studies of Apicularen A and Maoecrystal V

Viernes, Dennis Racca

… and biological evaluation of aminosteroids as inhibitors for the SH2-containing inositol phosphatase 1 (SHIP1). SHIP1, a 145 kDa protein, is involved in regulating the formation of new blood cells. High- throughput screening identified several SHIP inhibitors including NSC23922, a mixture of …

syracuse-diss Repository record for Synthesis, Design, and Biological Evaluation of Inhibitors and Activators of Src Homology 2 Domain-Containing Inositol Phosphatase (SHIP) and Synthetic Studies of Apicularen A and Maoecrystal V (opens in a new tab)