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Showing 1 to 20 of 31 for “"SH3 domain"”.

  1. INTERACTIONS OF ADAM15 SPLICE VARIANTS WITH SH3 DOMAIN PROTEINS

    Shedden, ElizabethUniversity of East Anglia2015

    … breast cancer progression. The intracellular domain (ICD) of ADAM15 exists in multiple splice variants that contain varied combinations of polyproline regions, which interact preferentially with proteins containing Src Homology 3 (SH3) domains. Patients suffering from node-negative breast …

    east-anglia Repository record

  2. Dynamic and kinetic investigations of SEM-5/SOS peptide interactions

    li chieh ChenThe University of Texas Medical Branch2009

    The dynamics of SEM-5 SH3 domain protein can provide an important insight into how structural dynamics contribute to protein function. This is important because solving the structure of protein alone only provides the detail on the population weight average of native ensembles. NMR (Nuclear …

    utmb Repository record

  3. STRUCTURAL AND BIOCHEMICAL CHARACTERIZATION OF DEUBIQUITINATING ENZYMES, SST2 AND SSEL

    Shrestha, Rashmi Kalicharan

    Associated molecule with SH3 domain of molecule (STAM), or AMSH, is a

    purdue-thes Repository record

  4. Exploring the Biophysical Properties of Domains Within Multi-Domain Proteins

    Muralidharan, Vasant

    … properties of proteins using small modular domains such as SH3 domains. However, there is a surprising lack of knowledge regarding how these properties are affected when the domain is placed back within its full-length multi-domain protein. Using a combination of expressed protein ligation …

    rockefeller Repository record

  5. Intestinal delivery of heterologous peptides with lactobacilli

    Zhang, LuyuUniversity of Illinois at Urbana-Champaign2015

    … wall of Lactobacillus spp. via cell wall binding domains. In this study, three non-covalent CWBD were selected including L. gasseri ATCC 33323 LysM domain-containing protein, L. gasseri ATCC 33323 Lysozyme M1, Bacterial SH3 domain and C-terminal membrane anchor domain of Lactococcus lactis subsp. …

    uiuc Repository record

  6. Competition Between Grb2 and Plcγ1 For Binding to Fgfr2 Regulates Phospholipase and Pten Activity, Leading to Cell Invasion and Proliferation

    timsah, zahra2015

    … aberrant signaling. In a novel interaction, the SH3 domain of Plcγ1 competes with the SH3 domain of Grb2 for binding to FGFR2 in a concentration-dependent manner. Consequently, reduction of cellular concentrations of Grb2 lead to receptor-dependent recruitment of unphosphorylated Plcγ1. Bringing …

    uthsc Repository record

  7. Structural-based Investigation of FAK and P130Cas in Focal Adhesion

    Zhang, Chi2016

    … proliferation and survival. The Src homology 3 (SH3) domain of p130Cas can directly interact with Focal Adhesion Kinase (FAK), which is a non-receptor tyrosine kinase that prominently locates in FAs. FAK serves the dual functions of recruiting p130Cas to FAs and recruiting Src kinase to …

    tenn-hsc Repository record

  8. The impact of protein fluctuations on molecular recognition

    anthony C mansonThe University of Texas Medical Branch2008

    … in the flexible RT loop of the C-terminal SH3 domain of\r\nSEM5. One set of mutations was designed to perturb the ensemble of accessible\r\nconformations in the unbound ensemble while leaving the interaction surface with the\r\nligand unchanged. The other set was designed to perturb both …

    utmb Repository record

  9. Analysis of the recruitment of the class I myosin Myo5p to endocytic sites in Saccharomyces cerevisiae

    Grötsch, HelgaUniversität Heidelberg

    … associate and dissociate at these membrane subdomains in a highly defined temporal order. The type I myosin Myo5p is an essential component of the endocytic machinery of S. cerevisiae. The protein has been shown to be localized to the cortical patches in a short time interval, preceding vesicle …

    heid-diss Repository record

  10. Affinity-based Growth Factor Delivery from Injectable Hydrogels for Tissue Engineering

    Vulic, Katarina2014

    … a polymeric delivery matrix. The Src homology 3 (SH3) domain, which binds a library of SH3-binding peptides, with varying affinity (10

    toronto-retro Repository record

  11. Protein/Peptide Recognition Modules in Cellular Signaling and HIV Pathogenesis

    Lee, Chi-Hon

    <p>The peptide-recognition domains play a key role in Eukaryotic signal transduction by mediating sequence-specific interactions with their protein/peptide ligands. In this thesis, I illustrate in molecular detail the recognition mechanisms utilized by three peptide-recognition domains: SH2 (Src …

    rockefeller Repository record

  12. MOLECULAR MECHANISMS OF THE FORMATION OF ENDOCYTIC PATCHES AND THE INITIATION OF ACTIN POLYMERIZATION IN FAST ENDOPHILIN MEDIATED ENDOCYTOSIS

    Narayan, Karthik, Balakrishnan2024

    … by multivalent interactions between EDP’s SH3 domain and the proline rich motifs found in its binding partners. The availability of the receptor TIL, which is a marker of receptor activation, promotes LPDEDP clustering on lipid membranes demonstrating how multivalent interactions regulate …

    penn Repository record

  13. Regulation of inflammatory TLR signalling by the BCAP adaptor

    Lauenstein, JohannesUniversity of Cambridge2020

    … rheumatoid arthritis. Through an N-terminal TIR domain, BCAP interacts with the MAL and MyD88 adaptors downstream of TLR activation. BCAP then recruits PI3K and PLC-𝛾2 to the TLR signalosome. Although these proteins can facilitate negative regulation of TLRs by endocytosis, the mechanism by which …

    cambridge Repository record

  14. Toca-1 driven actin polymerisation at membranes

    Fox, Helen MaryUniversity of Cambridge2018

    … fulfil such a role have a membrane interacting domain (such as the PH domain in lamellipodin, or I-BAR protein in IRSp53) and a domain which interacts with actin regulatory proteins (such as the SH3 domain of IRSp53, which binds Ena and VASP). I investigated the contribution of the F-BAR protein …

    cambridge Repository record

  15. Protein-Protein Interactions and Muscle cell Signaling Via Syntrophin

    Oak, Shilpa A.2016

    … localized to the N-terminal pleckstrin homology domain (PH1) or adjacent sequences; the second, C-terminal PH2 domain did not show oligomerization. PH1 was found to se lf-associate and calmodulin or Ca<sup>2+</sup> chelating agents such as EGTA could effectively prevent this oligomerization. A …

    tenn-hsc Repository record

  16. Investigating the role of ICL3 in β1-adrenergic receptor activation

    Tandale, AditiUniversity of Cambridge2022

    … by creating a chimera of tβ1AR transmembrane domain with the flexible ICL3 from human β1AR (hICL3). The position of ICL3 is close to the G protein binding site and hypothesized to have a role in binding specificity of the receptor with intracellular binding partners. This thesis provides a …

    cambridge Repository record

  17. AFAP-110 is a cSrc activator

    Baisden, Joseph Myers2019

    … transformed cells. Mutation of protein binding domains (SH2 and SH3) from cSrc results in the deregulation of the kinase and the transformation of cells, while deletion of these domains blocks transformation by active forms of Src. This indicates that SH2/SH3 binding partners for cSrc may play a …

    wvu Repository record

  18. Biochemical and genetic analysis of the adaptor protein SH3P7 : insights from a newly generated knockout mouse

    Connert, Sabine

    SH3P7 (mAbp1/Hip55) is a widely expressed actin-binding adaptor protein identified as a substrate for protein tyrosine kinase (PTK) after BCR activation. In addition to two protein-binding modules specific for filamentous actin, SH3P7 also contains an SH3 domain. The biochemical studies presented …

    freiburg-diss Repository record

  19. Functional Characterization of Amphiphysin in Drosophila melanogaster

    Chow, Brenda Marilyn2012

    Amphiphysin (Amph) is a multi-domain protein that has been implicated in synaptic vesicle (SV) endocytosis. In vertebrates, Amph1 associates with SVs and binds to known endocytic proteins, such as dynamin and clathrin. Overexpression of the vertebrate Amph1 SH3 domain is sufficient to inhibit SV …

    toronto-retro Repository record

  20. Understanding Membrane Curvature Sensing

    Colussi, AdelineUniversity of Cambridge2017

    … to track fluorescently labelled lipid-binding domains bound to liposomes of different sizes moving freely in solution. The comparison of the size distribution of the total liposomes with the fluorescently labelled population allowed me to determine their curvature preferences. To validate the …

    cambridge Repository record

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