Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 16 of 16 for “"SH-SY5Y cell"”.
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Effects of Natural Antioxidants on Motor and Cognitive Deficits in an Animal Model of Aging and Obesity and Dopaminergic-Like SH-SY5Y Cell Line
… anti-cancer properties and is also shown to be neuroprotective. During the course of our study, an unexpected confounding factor in the form of weight gain was introduced. However, by controlling for the increased bodyweight, we were able to evaluate resveratrol-mediated behavioral …
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The Role of FBXO7 in Mitochondrial Biology and Parkinson's Disease
… a variety of other atypical functions, such as cell cycle regulation, proteasome regulation, and mitophagy. The overall aim of this research was to characterise the functional role of FBXO7 in various in vitro and in vivo PD models. The models examined included FBXO7 shRNA knockdown SH-SY5Y cell …
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Monoamine oxidase in neuronal cell death
… (ROS) contribute to oxidative stress in the cell and can directly inhibit electron transport, cause damage to mitochondrial DNA and enhance cell death signalling. In this study the role of MAO in cell death was investigated in dopaminergic neuroblastoma (SH-SY5Y) cells, in three diverse …
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5-HT1A receptor expression : Studies in postmortem tissue and characterisation of a model system.
… Kd quantifying 5-HT[1A] receptor density. The SHSY-5Y neuroblastoma cell line is a well characterised cell line model used in neurotransmitter studies when differentiated. The 5-HT[1A] receptor couples to Gi proteins inhibiting AC activity and hence mediating a variety of intracellular changes …
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Synthesis of novel vanillin derivatives: study of their antioxidant and potential neuroprotective properties.
… class of compounds. A structure-activity relationship (SAR) was therefore determined. The tetramer 4c turned out to be the most efficient antioxidant in all the assays. The latter compound consists of four vanillin moieties, together with a molecular structure that facilitates electron …
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Small Molecules Targeting and Modulating Toxic Tau Oligomeric Strains
… (NFTs) and oligomers. Recently, it has been shown that tau oligomers are highly toxic in vitro and efficient seeds for the propagation of pathology as compared to NFTs. While the toxicity of recombinant tau oligomers has been studied extensively, within the same aggregation state, tau …
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Effects of oxidative stress and neuroprotection in apoptosis in neuronal cell models
The PC12 and SH-SY5Y cell models have been proposed as potentially realistic models to investigate neuronal cell toxicity. The effects of oxidative stress (OS) caused by both H2O2 and Aβ on both cell models were assessed by several methods. Cell toxicity was quantitated by measuring cell viability …
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Microglial Modulation of Neuronal Autophagy: Uncovering Cytokine-Mediated Pathways
Autophagy, a conserved cellular degradation process, plays a critical role in clearing toxic protein aggregates. Its disruption has been linked to various pathological conditions, including neurodegenerative diseases. Mutations in autophagy-related genes are found in a subset of hereditary …
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In vitro investigation of the molecular relationship between mitochondrial dysfunction and neurogenesis in autism aetiology
… the inaccessibility of the developing brain, cell culture model systems are needed to investigate the molecular relationship between mitochondrial dysfunction and neuronal differentiation as it pertains to ASD aetiology. A key differentially methylated gene was Propionyl-CoA Carboxylase …
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Silicon nanopore patch clamp device for measuring single ion channel activity
… seal between a glass micropipette and a cell membrane. This transformative method allows low noise recording of current arising from single ion channels or from an entire cell and has no equivalent in experimental neuroscience. However, the consistent formation and maintenance of a high …
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Wpływ przepływu mikrofluidycznego oraz nanocząstek metalicznych na właściwości amyloidogenne ludzkiej cystatyny C
… i bardziej heterogeniczny. Badania na komórkach SH-SY5Y wykazały, że formy powstałe po inkubacji HCC z CuO NPs znacznie obniżają żywotność komórek oraz zwiększają poziom reaktywnych form tlenu. Wyniki pokazują, że nanocząsteczki CuO wpływają na przebieg przemian HCC - od destabilizacji struktury …
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Mechanism of Action of Nicotinamide Phosphoribosyltransferase Mediated Signaling in Oxidative Stress
… stress. Neuroprotection and protection of cells supporting the function of neurons could provide novel therapeutic approaches to treating and preventing neurodegenerative diseases when therapies do not exist or existing therapies fail (3). Nicotinamide phosphoribosyltransferase (Nampt) is …
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Maternal stress signature and infant neurodevelopment: determining the beneficial effects of human milk oligosaccharides - an in vitro study
… roles in many essential functions, including shaping the gut microbiota, inhibiting pathogen adherence to prevent infection, development of the infant immune response, anti-inflammatory properties, gastrointestinal barrier function and brain development. Recent studies have found that not only …
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Defining the potential of HDAC5 and HDAC9 as therapeutic targets for Parkinson’s disease
… enzymes which regulate histone acetylation, have shown some promise in this regard. For example, pan-HDAC inhibition by pharmacological compounds in PD models have been reported to provide some neuroprotection in PD models. However, given the number of different classes of HDACs (ClassI-IV) and …
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Formazione di proteine canale: dal mitocondrio a SARS-CoV-2. Caratterizzazione funzionale e strutturale attraverso l'uso di tecniche respirometriche e di dinamica molecolare
… perché favoriscono il passaggio da un ambiente cellulare all’altro, regolando i vari processi cellulari. Tra le principali porine riconosciute, vi è VDAC (Voltage Dependent Anion Channel), che tra le sue funzioni ha il trasporto di numerose molecole, tra cui ioni e metaboliti vari, tra cui …