Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 111 for “"SH-SY5Y"”.
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A study of the neurotoxicity of MPTP and analogs in human neuroblastoma SH-SY5Y cells
… (MPTP) in an in vitro model SH-SYSY human neuroblastoma cells were explored using cytotoxic effects, neurochemical changes and pathological injury as endpoints. The results suggested that: MPTP entered the SH-SYS5Y human neuroblastoma cells through a non-dopamine transport …
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The effects of Parkinson's disease mimetics on the proteasomal and neurofilament systems in SH-SY5Y cells
… the various activities of the proteasome in SH-SY5Y human neuroblastoma cells treated with the PD mimetics MPP+ (a complex I inhibitor) or dopamine. Treatment with these toxins led to dose and time dependent reductions in ATP and glutathione levels and also chymotrypsin-like and …
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DIFFERENTIATION-INDUCED CHANGES IN ANTIOXIDANT CAPACITY AND ANTIOXIDANT RESPONSE IN SH-SY5Y CELLS: ROLE OF NRF2
… using undifferentiated and differentiated SH-SY5Y neuroblastoma cells. The investigations of this study focused on the induction of antioxidant enzymes in SH-SY5Y cells by Nrf2 using tert-Butylhydroquinone (tBHQ). The levels of GSH, Mn-SOD, HO and OGG1 which are all induced by Nrf2 were …
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DIFFERENTIATION-INDUCED CHANGES IN ANTIOXIDANT CAPACITY AND ANTIOXIDANT RESPONSE IN SH-SY5Y CELLS: ROLE OF NRF2
… using undifferentiated and differentiated SH-SY5Y neuroblastoma cells. The investigations of this study focused on the induction of antioxidant enzymes in SH-SY5Y cells by Nrf2 using tert-Butylhydroquinone (tBHQ). The levels of GSH, Mn-SOD, HO and OGG1 which are all induced by Nrf2 were …
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Oleoylethanolamide and palmitoylethanolamide synergize with IFNβ to potentiate apoptosis and PD-L1 induction in SH-SY5Y neuroblastoma cells
… could modulate IFNβ-induced responses in human SHSY5Y NB cells. Through a combination of viability assays, scratch wound healing, clonogenic assays, and western blotting, we show that OEA and PEA significantly enhance IFNβ-mediated cytotoxicity. Co-treatment with IFNβ and either lipid …
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Protective effects of Human Bone Marrow-Derived Mesenchymal Stem Cells on Apoptosis Induced Human Neuroblastoma SH-SY5Y Cells
… transwell have effects against apoptosis induced SH-SY5Ys. SH-ST5Ys were treated with 0.25？？M Stausrosporine(STS) for 24hrs to induce apoptosis. The media of hMSCs was collected after 2days of hMSC culture and added into STS-treated SH-SY5Ys. hMSCs plated in transwell were cocultured with …
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Effects of Natural Antioxidants on Motor and Cognitive Deficits in an Animal Model of Aging and Obesity and Dopaminergic-Like SH-SY5Y Cell Line
… anti-cancer properties and is also shown to be neuroprotective. During the course of our study, an unexpected confounding factor in the form of weight gain was introduced. However, by controlling for the increased bodyweight, we were able to evaluate resveratrol-mediated behavioral …
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The effect of glucagon-like peptide-1 (GLP-1) receptor agonists on cell viability, ADAM10 maturation and the proteolysis of ADAM10 substrates in SH-SY5Y cells
… conditions such as AD, as they have been shown to exert neuroprotective properties. Research has also suggested that one of these compounds, exendin-4, can enhance the amount of membrane-associated ADAM10. The current study, therefore, aims to determine firstly; whether GLP-1 analogues can …
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Nanotechnology based therapeutic approaches to iron‐induced oxidative stress in an in vitro model of Parkinson’s disease
… protect against rotenone‐induced parkinsonism in SH‐SY5Y cells, and in a co‐cultured hCMEC/D3 ‐ SH‐SY5Y cellular BBB model. In Parkinson’s disease (PD), excess free iron drives the accumulation of toxic hydroxyl radicals within mitochondria of dopaminergic neurons, resulting in sustained oxidative …
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Genomic and non genomic effects of elevated concentration of anabolic steroids in human neuronal cells
… of mu opioid receptor (MOPr) transcripts in SH-SY5Y human neuroblastoma cells. This effect was prevented by the androgen receptor (AR) antagonist hydroxyflutamide. Receptor binding assays confirmed a decrease in MOPr of approximately 40% in nandrolonetreated cells. Treatment with actinomycin …
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In vitro investigation of the molecular relationship between mitochondrial dysfunction and neurogenesis in autism aetiology
… are needed to investigate the molecular relationship between mitochondrial dysfunction and neuronal differentiation as it pertains to ASD aetiology. A key differentially methylated gene was Propionyl-CoA Carboxylase Subunit B (PCCB), a mitochondrial enzyme involved in metabolizing short fatty …
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The relationship between the infection of Toxoplasma gondii and Alzheimer’s disease
… using the development of a model system. SH-SY5Y cells were used as culture models for neuronal cells and flow cytometry and MTT assays were conducted to determine cell viability. To evaluate the effects of oxidative stress, differentiated and undifferentiated SH-SY5Y cells, were examined …
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Neuronaalisten kolinergisten nikotiinireseptorien positiivinen ja negatiivinen allosteerinen modulaatio
… opioids, codeine, oxycodone and tramadol in SH-SY5Y cells. SH-SY5Y cells express endogenously α3* and α7-nAChRs. Binding assays were performed with radioactive ligand [3H]-epibatidine. Functional interactions of nicotine and the opioids were studied with 86Rb+- efflux assay. Codeine, …
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5-HT1A receptor expression : Studies in postmortem tissue and characterisation of a model system.
… Kd quantifying 5-HT[1A] receptor density. The SHSY-5Y neuroblastoma cell line is a well characterised cell line model used in neurotransmitter studies when differentiated. The 5-HT[1A] receptor couples to Gi proteins inhibiting AC activity and hence mediating a variety of intracellular changes …
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Developmental Appearance of Phosphorylated Intermediate Filaments in Nuclei of Glioma and Neuroblastoma Cells
… can be found in the nuclei of F98 glioma and SH-SY5Y neuroblastoma cells, respectively, under conditions of cell growth or differentiation was investigated. I identified the growth stages of cells grown in culture by determining growth rates as a function of cell density, and I identified …
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Maternal stress signature and infant neurodevelopment: determining the beneficial effects of human milk oligosaccharides - an in vitro study
… roles in many essential functions, including shaping the gut microbiota, inhibiting pathogen adherence to prevent infection, development of the infant immune response, anti-inflammatory properties, gastrointestinal barrier function and brain development. Recent studies have found that not only …
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Characterising the role of GPR50 in neurodevelopment and lipid metabolism
… metabolism. The work presented in this thesis shows that GPR50 promotes neuronal differentiation. Overexpression significantly increased the number of neurites per cell in SH-SY5Y cells. Further, dendritic branching was enhanced by GPR50 transfection in hippocampal and cortical neurons (DIV …
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The effects of catalase and kisspeptin overexpression on amyloid peptide toxicity
… Aβ deposits. The immunohistochemistry results show that immunoreactive KP or immunoreactive catalase co-localizes with immunoreactive Aβ in AD pons sections. These results suggest that endogenous catalase and KP could play neuroprotective roles in AD. Catalase and KiSS-1 overexpressing gene …
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