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Showing 1 to 2 of 2 for “"SH-11037"”.
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Mechanistic and therapeutic evaluation of a novel antiantiogenic small molecule
… or combine with existing medications. I studied SH-11037, a novel homoisoflavonoid with potent and selective antiangiogenic activity against human retinal endothelial cells. Intravitreal SH- 11037 dose-dependently suppressed angiogenesis in the laser-induced CNV (LCNV) mouse model. These effects …
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The molecular mechanism of action of the antiangiogenic natural product, cremastranone
… and optimize its structureactivity relationship (SAR). In order to achieve this goal, with the help of chemistry collaborators cremastranone was synthesized for the first time. I showed that cremastranone has 50-fold more potency against endothelial cells as compared to nonendothelial cells, …