Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 13 of 13 for “"SGK1"”.
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Sgk1 como mediador de los efectos deletéreos del receptor de mineralocorticoides
… effects of MR. In this context we studied SGK1, a transcriptional target of MR that increases tubular Na+ reabsortion and salt appetite. SGK1 has been involved in several fibrotic diseases and adipogenesis. This work investigates the role of SGK1 in MR-induced processes that lead to an …
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The role of Serum- and Glucocorticoid kinase in the hormonal control of sodium transport in pulmonary epithelia
… role for serum- and glucocorticoid-kinase(SGK1). The activity of this kinase is dependent upon phosphorylation of two distinct residues by the target of rapamycin complex 2 (TORC2) and phosphoinositidedependent Kinase 1 (PDK1), both of which are dependent upon Phosphoinositide-3-Kinase …
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ETHANOL REGULATION OF GLUCOCORTICOID RESPONSIVE GENES
… Serum and Glucocorticoid-regulated Kinase 1, Sgk1, is prominently up regulated by acute ethanol (2 g/kg) in the prefrontal cortex (PFC) of DBA/2J mice. Functionally, Sgk1 is an important focal point of intracellular signaling cross-talk through which the cell surface receptors, nuclear …
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The signalling pathways allowing hormonal regulation of Na+ transport in murine collecting duct cells
… Selective inhibition of PI3-kinase, mTORC2 and SGK1 left ~80 % of the current intact, indicating these signalling molecules are not required for basal Na+ transport. Acute addition of insulin stimulated Ieq and this occurred with a concomitant increase in mTORC2, SGK1 and Akt activity. …
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Hormone-induced expression of the epithelial sodium channel in human airway cells
… / glucocorticoid-inducible protein kinase 1 (SGK1) and protein kinase A (PKA) in the responses of hormone-stimulated H441 human airway cells. Dexamethasone, a synthetic glucocorticoid hormone, is thought to evoke expression of the gene encoding SGK1 and, to become catalytically active, this …
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Exploring the Glucocorticoid Actions of 1α-Hydroxycorticosterone (1α-OH-B) in the Elasmobranch Fishes
… serum- and glucocorticoid- inducible kinase 1 (SGK1). <em>SGK1 </em>mRNA abundance was upregulated in red blood cells incubated with 1α-OH-B. The results of these studies support the putative GC actions of 1α-OH-B, including the correlation of 1α-OH-B with basal glucose <em>in vivo </em>and the …
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EARLY LIFE STRESS EXPOSURE AND HYPOTHALAMIC PITUITARY ADRENAL AXIS: FROM MECHANISMS TO PERIPHERAL BIOMARKERS OF VULNERABILITY
… è stato dimostrato il ruolo chiave del gene SGK1 (Serum-and Glucocorticoid-inducible Kinase 1) come marcatore della vulnerabilità allo stress, in questo progetto ho utilizzato un approccio multi-tessuto e multi-specie che mi ha consentito di confrontare i dati ottenuti in un modello animale …
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WNK Family Kinases and the Regulation of Ion Flux
… serum- and glucocorticoid-inducible kinase 1, SGK1, leading to the internalization of the epithelial Na+ channel, ENaC via the ubiquitin ligase neuronal precursor cell- expressed, developmentally downregulated protein 4-2, or Nedd4-2.
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Analysis of the role of the mineralocorticoid receptor in renal principal cell sodium reabsorption in vivo
… serum- and glucocorticoid-regulated kinase 1 (Sgk1) and the ubiquitin-specific protease 2 (Usp2). Quantitative RT-PCR on microdissected CDs from control mice and principal cell MR-deficient (MRAQP2Cre) mice under low-sodium diet showed that the gene expression levels of Sgk1 and the …
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Characterizing Changes in the Brain During Hydrocephalic Development and Exploring Potential Treatment Strategies
… Serum and glucocorticoid-regulated kinase 1 (SGK1) is a kinase implicated in cell volume regulation and CSF production. SI113, an SGK1 inhibitor, ameliorates hydrocephalus in the Tmem67 rodent model. The goal of this study was to determine if SI113 could be used with a new solvent other than …
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Global characterization of oncogenic kinase signaling
… The 3D screens identified of 9 kinases (e.g. SGK1, DAPK1, NEK7, and LIMK2) essential for Src-induced transformation, while MAK4K5 promoted acini growth. This study not only characterized the Src-regulated kinome involved in oncogenesis for the first time, but also provided novel therapeutic …
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Pan-Cancer Analysis of Non-Coding Driver Mutations
… regions, including novel candidates like the SGK1 splice site, GPR126 enhancer and ALB promoter. To test whether the surprisingly low number of non-coding drivers is related to missing drivers in poorly-defined genomic regions, I investigate non-coding spliceosomal RNAs since protein-coding …
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The Regulation of Glucose Metabolism during Osteoblast Differentiation
… glucose utilization required IGF-PI3K-SGK1 signaling. Importantly, pharmacological enhancement of pyruvate entering the TCA cycle attenuated the bone anabolic effect by PTH. Thus, changes in cellular glucose metabolism may be an important mechanism mediating the anabolic effect of …