Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 3 of 3 for “"SFXN3"”.
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Mitochondrial protein SFXN3 as a novel target in neurodegenerative diseases
… of synaptic pathology, and Sideroflexin 3 (SFXN3) was identified as a mitochondrial protein that modulates synaptic morphology in vivo. This finding prompted the aims of this thesis: biochemical characterisation of SFXN3; the identification of SFXN3’s molecular interactors and the …
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Investigating novel therapeutic approaches and targets to prevent synapse degeneration
… vitro cell systems we identified sideroflexin 3 (sfxn3). We show sfxn3 is localized at the inner mitochondrial membrane and that it functions outside the main canonical pathways of mitochondria energy production. In addition, overexpression of sfxn3 in Drosophila led to a significant loss of …
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Sideroflexins enable mitochondrial transport of polar neutral amino acids
… and gammaaminobutyric acid (GABA). SFXN2 and SFXN3 partially complemented loss of SFXN1 to enable glycine transport, while SFXN2 and SFXN5 partially complemented loss of SFXN1 to enable GABA transport. Altogether, this work suggests that sideroflexins regulate the delivery of polar neutral …