Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 2 of 2 for “"SFTPC"”.
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Identification and characterisation of novel interactors of surfactant protein C
… pathogenic variants of surfactant protein C (SFTPC) can cause familial pulmonary fibrosis. The most common, SFTPC-I73T, aberrantly localises to the plasma membrane and causes alveolar type 2 (AT2) dysfunction via a poorly understood toxic gain-of-function. Understanding the mechanisms of SFTPC …
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A study of the causes and consequences of SFTPC mistrafficking in alveolar type 2 cells using novel organoid models
… by pathogenic variants of surfactant protein C (SFTPC), offer an opportunity to study these early events. The commonest pathogenic mutation, SFTPC-I73T, results in aberrant accumulation of immature protein at the plasma membrane and in early endosomes resulting in a toxic gain-of-function …