Global ETD Search
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Showing 1 to 6 of 6 for “"SFRP4"”.
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Mechanisms of defective insulin secretion in type 2 diabetes
… overexpressed in islets from T2D patients is SFRP4, which encodes secreted frizzled-related protein 4. SFRP4 expression correlated with inflammatory markers, and its release from islets was stimulated by interleukin-1B. Elevated systemic SFRP4 caused reduced glucose tolerance through decreased …
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Die differentielle Expression tumorfördernder und tumorinhibierender Gene im ersten und zweiten Trimester der Schwangerschaft
… down-regulation could be shown for three (SLPI, SFRP4, CXCL14) and an up-regulation for one (CXCL9) when comparing the first to the second trimester. In addition, one marker’s up-regulation (SLPI) could be further verified on protein level. The results of this study show that genes promoting …
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Untersuchungen über Veränderungen des Epigenoms bei der chronischen lymphatischen Leukämie
… (65.6%), DAPK1 (50.0%), E cadherin (21.9%), SFRP4 (15.6%), SOCS3 (15.6%), p15 (9.4%), p16 (6.3%), RARbeta2 (3.1%), SFRP5 (3.1%) und TIMP3 (3.1%). For DAPK2, hMLH1, MGMT, p73, SOCS1 and TIMP2 no hypermethylation was detected. Hypermethylation of at least one gene was observed in 90.6% of the …
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Relationship of the glycation gap to diabetes and its complications, and the potential role of adipokines
… of some adipokines (WISP1, eNAMPT/Visfatin, sFRP4) on insulin secretions/release from pancreatic beta cell. To this end, MIN6 cells were cultured in low and high glucose media, treated with different concentrations of adipokines, and tested for insulin secretion, beta cell failure and cell …
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Effects of early nutrition on the wnt and bone morphogenic protein pathways in the developing intestine
… The mRNA expression of β-catenin, sFRP3, sFRP4, frizzled 6, DKK1 (Wnt pathway), gremlin (BMP pathway), TNF-a, HNF-4α and osteopontin (OPN) was measured by RT-qPCR. Piglets fed the F+P diet had greater acetate concentration and lower pH in the ileum at day 14 and in the colon at day 7 and …
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Identifizierung und Charakterisierung von Genen für die Entwicklung der Nieren und des Urogenitalsystems
… die mit den Expressionsmustern von sFRP1 und sFRP4 verglichen wurde. Die detailierte Genexpressionsanalyse der sFRP-Familie in der murinen Embryonalentwicklung sollte als Grundlage für funktionelle Studien dieser erst kürzlich entdeckten neuen Genfamilie dienen. Erste Untersuchungen der …