Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 10 of 10 for “"SFRP"”.
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Hypermethylierung-assoziierte Dysregulation der WNT-Antagonisten SFRP 1, 2, 4 und 5 beim Multiplen Myelom
… that concurrent promoter hypermethylation of SFRP genes is a common epigenetic event in MM. We found that aberrant methylation of at least one gene occurred in 48/76 (63.2%) samples. SFRP 1 and SFRP 2 were the most frequently affected genes. Hypermethylation of SFRP genes could be observed in …
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Zur epigenetischen Inaktivierung der Wnt-Antagonisten SFRP-1, -2, -4 und -5 bei der Akuten Myeloischen Leukämie
… family of secreted Frizzled-related proteins (SFRPs), functioning as Wnt signaling antagonists, has been found to be downregulated by promoter hypermethylation in acute lymphoblastic leukaemia (ALL) and solid tumors. Data suggest a correlation between epigenetic silencing of SFRPs and poor …
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Wnt Modulators, Secreted Frizzled Related Protein (sFRP) 2 and Wnt Inhibitory Factor (WIF)-1, Stimulate Melanogenesis in Normal Human Melanocytes
… high levels of frizzled-related protein 2 (sFRP2) and Wnt inhibitory factor-1 (WIF-1) compared to perilesional normal skins. In this study, I investigated the functional roles of sFRP2 and WIF-1 on skin pigmentation. The present study demonstrated that sFRP2 and WIF-1 were expressed in both …
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Strengthening of timber beams using externally-bonded sprayed fibre reinforced polymers
… form of a spray. Externally bonded Sprayed FRP (SFRP) is known to increase strength and energy absorption capacity of a retrofitted member as well as, or better than, FRP sheets. However, tests have primarily been carried out on concrete members only. An area of interest, into which not much …
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Die Wnt-Signalkette in der Pathophysiologie der kongenitalen obstruktiven Uropathie der Ratte
… der secreted Frizzled-related proteins (sFRP-1 und -2), von ß-Catenin sowie der Jun N-terminalen Kinase (JNK) war erhöht. Die Genexpression von Wnt-7b, Frizzled-1 und -2, Calcineurin sowie dem Wnt-Inhibitory Factor (WIF-1) war unverändert. Bei den Nieren der 32 Tage alten Tiere war die …
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Wnt signaling in commissural axon guidance
… are known Wnt antagonists. We could show that Sfrp1 is expressed in a gradient and is able to modulate Wnt activity. Downregulation and upregulation of Sfrp1 phenocopies guidance errors seen after modulation of Wnt expression. Therefore, a Wnt activity gradient, shaped by Sfrp, guides …
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Synthesis and Characterization of Tailored Macromolecules via Stable Free Radical Polymerization Methodologies
… acrylate) was synthesized using the SFRP process. The t-butyl functionalities were subsequently removed in a post-polymerization acid catalyzed hydrolysis. The effect of steric bulk and electronic factors on the resulting SFRP process was also investigated and revealed similar …
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Wnt Secretion Proteins Modulate RANKL-Induced Expression of Aire in Thymic Epithelial Cells
… Our results show that the Wnt antagonist, Sfrp-1, and the Wnt ligand, Wnt-5b, interfere with RANKL-induced maturation as demonstrated by a reduced frequency of Aire+ fetal TECs. Furthermore, we show two proteins that are hallmarks of thymic development, FoxN1 and Dll4, regulate Wnt-5b …
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Effects of early nutrition on the wnt and bone morphogenic protein pathways in the developing intestine
… was measured. The mRNA expression of β-catenin, sFRP3, sFRP4, frizzled 6, DKK1 (Wnt pathway), gremlin (BMP pathway), TNF-a, HNF-4α and osteopontin (OPN) was measured by RT-qPCR. Piglets fed the F+P diet had greater acetate concentration and lower pH in the ileum at day 14 and in the colon at day …
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Identifizierung und Charakterisierung von Genen für die Entwicklung der Nieren und des Urogenitalsystems
… ausgewählt. Als eines der bekannten Gene wurde sFRP2 als im metanephrogenen Mesenchym induziert bestätigt und durch in situ Hybridisierung ganzer Mäuseembryonen und Paraffinschnitte näher untersucht. Es zeigt eine spezifische und dynamische Expression während der Entwicklung der Niere und …