Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 23 for “"SFK"”.
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The role of SRC family kinases in the development and progression of prostate cancer
… Src family of non-receptor tyrosine kinases (SFK) represent proteins involved in the development of various solid malignancies, including prostate cancer. These proteins are often found on the cross-roads of intracellular pathways, integrating molecular systems into complex signalling …
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Signal transduction in macrophages. Intracellular pathways activated by microbial constituents
… tyrosine kinases from the Src family (SFK) and the Tec kinase Btk. in signaling pathways induced by microbial constituents. SFK are important in bacteria and yeast induced arachidonate release and these studies bring forward that SFK has a pivotal role in acting proximally of several …
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Epidermal Growth Factor Receptor Induces Fyn Expression Via Up-Regulation of P47Phox In Glioblastoma Multiforme
<p>Src family kinases (SFKs) are commonly over-expressed and/or activated in glioblastoma multiforme (GBM), where they serve as key mediators of GBM cell proliferation, survival, invasion and angiogenesis. Mechanisms of allosteric SFK activation are well described; however, the SFK Fyn is commonly …
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CAVEOLAE AS SPATIO-TEMPORAL COMPARTMENTS FOR ROS/RNS GENERATION AND NITROXIDATIVE STRESS SIGNALING
… antibody revealed Src-family kinases (SFK) in the precipitated fraction. Moreover, SFK nitration was lost in cells depleted of caveolin-1. Given that SFK nitration is associated with enzyme activation, cells were pretreated with PP2 to inhibit SFK activity. We found that PP2 attenuated …
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Dissecting the molecular mechanisms of therapeutic resistance in cancer
… 1-induced EMT, I found that Src family kinases (SFKs) were activated within 24 hours of ZEB 1 expression. Inhibition of SFKs blocked not only ZEB 1-induced EMT, but also EMT initiated by TGFp- and EGF signaling pathways in both breast and NSCLC cell-lines. SFK inhibition also prevented EGFR …
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Novel peptide-based approaches to study the activity and substrate specificity of protein kinases
… monitoring the activity of Src-family kinases (SFKs) in vitro and in lysates of cancer cells and primary mammalian cells via fluorescence. Click chemistry was first used to install a series of fluorophores into the optimal phosphorylation sequence of SFKs and then experiments conducted to …
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Tumor cell-intrinsic signals promoting tolerance and adaptation to oncogenic kinase inhibition
… that sustained activity of SRC family kinases (SFKs), or of the SRC-like kinases ABL1/2, is an important contributor to GM-TKI tolerance in all lines. In the second part, I have examined the molecular events underlying drug-induced adaptation, the process by which drug exposure inadvertently …
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Rôles et mécanismes d'action du récepteur AT[indice inférieur 2] de l'angiotensine II d'un modèle cellulaire neuronal au tissu prostatique humain l'importance du contexte
… des membres de la famille des kinases Src (SFK) dans les voies de signalisation menant à l'élongation neuritique induite par le récepteur AT2 , 2) caractériser le M24 et un autre composé, le M132, sur les voies de signalisation et leurs effets dans les cellules NG108-15 et 3) vérifier …
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Investigating PLEKHS1 adaptor function in PI3K signalling and human cancer biology
… and PI3K interaction are driven by SFK activity and independent of serum growth factors. In this context and alike *in vivo* findings, the PLEKHS1 PH domain which specifically binds PIP<sub>3</sub> and PI(3,4)P<sub>2</sub> mediates positive feedback PI3K activation. PLEKHS1 adaptor …
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Identification of novel biomarkers for clinical prognosis in breast cancer
… c-RAF-1, ERK-1/2, AKT, LYN, SRC family kinases (SFKs) and NFκB (p50 RelA) were analysed in combination with SK1 and S1P receptors to discover novel prognostic interactions that drive cancer progression in ERα positive breast cancer patients. High tumour SK1 expression in combination with high …
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Molecular Drivers of Bladder Cancer Motility
… following exposure to the Src Family Kinase (SFK) inhibitor AZD0530, only luminal models are sensitive to the anti-invasive effects of the compound. I also explore the correlation between the developmental program, EMT, and invasion in a panel of BC cell lines. Models could be broadly …
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Estudio de los coactivadores transcripcionales TAZ y YAP1 en el sarcoma de Ewing: Implicación en la progresión tumoral e interacción funcional con la proteína de fusión EWS-FLI1
… aberrante de TAZ/YAP1 a través de las kinasas SFK, en un proceso independiente de la vía Hippo. Nuestro estudio revela un antagonismo transcripcional entre la actividad de TAZ/YAP1 y la proteína de fusión EWS-FLI1, que, junto con la activación de la vía Wnt, podría contribuir a un estado más …
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Investigating a co-operative link between TGF-β and Lyn kinase in Chronic Myeloid Leukaemia
… of Lyn, a member of the Src family kinases (SFK). The main aim of the project was to investigate whether transforming growth factor-β (TGF) might influence drug-resistance through direct affects on Lyn kinase levels and its activation. This research builds on previous findings of …
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MOLECULAR PHYSIOLOGY OF THROMBOXANE A2 GENERATION IN PLATELETS
… activation of FAK was integrindependent and SFK-independent. On the other hand selective activation of G12/13 pathway lead to FAK activation, in SFK and Rho dependent manner. We also evaluated specificity of new FAK inhibitor TAE-226 to understand the role of FAK in TXA2 generation. Our …
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CLEC-2 SIGNAL TRANSDUCTION IN PLATELET ACTIVATION
… abolished by the pan-Src family kinase (SFK) inhibitor, PP2, or when Syk is inhibited. PP2 abolished phosphorylation of Syk and Phospholipase Cγ−2. Fucoidan-induced platelet activation had a lag phase, which is reminiscent of platelet activation by collagen and CLEC-2 receptor agonists. …
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Role of Phosphorylation of Focal Adhesion Kinase At Tyrosine 861 In Prostate Cancer Metastasis
… in expression and total activity of the SFK, Yes, but no other members of the Src family kinases. I demonstrated that Yes was specifically responsible for the phosphorylation of FAK Y861 using both prostate tumor cells and <em>src-/-</em>,<em> yes-/-</em>,<em> fyn-/-</em> mouse embryo …
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Regulation and Targeting of Fyn in Human Cutaneous Squamous Cell Carcinoma
… but did not increase the expression of other SFKs. We identified two nucleotides 74 bases upstream of the human FYN gene transcription start site as necessary for FYN upregulation in HaCaT-Ras cells. Further studies identified Lef-1 as the transcription factor most likely binding to this site …
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The Role of Il-8-Mediated Src Family Kinase Activation In Tumor-Tumor and Tumor-Stromal Interactions In Metastasis of Prostate Cancer
… tyrosine kinases, including Src Family Kinases (SFKs) contribute to metastasis through numerous functions, one of which leads to increased expression of cytokines, such as IL-8. However, the relationship between Src activity and IL-8 regulation is not completely understood. In cell line models, I …
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Function, expression and evolution of the *Src family kinases in Caenorhabditis elegans
… common ancestor with one of the two invertebrate SFK. Finally, I developed a novel proteomic approach to identify targets of Src tyrosine kinase signaling as part of a long term goal to understand the pathways and biological role of SFKs in metazoans. Collectively, this research contributes to a …
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Immunostimulatory properties and mechanisms of action of encapsulated methylated cpg oligodeoxynucleotides
… of CpG ODN, allowing for the activation of SFK signalling resulting in subsequent co-localization of TLR9 and mCpG ODN in the endosome thus initiating immunostimulatory activity.
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