Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 9 of 9 for “"SET1"”.
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The Role of the Set1 RNA Polymerase II Interacting Motif (SRIM) in Set1 Recruitment and Histone H3K4 Methylation
… been associated with transcription activation. Set1 is the sole H3K4 histone methyltransferase in Saccharomyces cerevisiae and functions in a multi-subunit protein complex (Set1C) to catalyze H3K4 mono-, di-, and trimethylation. In addition, mis-regulation of Set1 human orthologs such as MLL (1 …
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Regulation of Set1-Mediated Methylation of Dam1
… cerevisiae</em>, H3K4 methylation is mediated by Set1 within the COMPASS complex. Methylation requires prior ubiquitination of histone H2BK123 by the E2-E3 ligases Rad6 and Bre1, as well as the Paf1 transcriptional elongation complex. This regulatory pathway exemplifies cross-talk <em>in …
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Thermodynamic and Structural Characterization of the Interaction between Wd40 Repeat Containing Protein 5 (Wdr5) and Human Set1 Family Methyltransferases
… leukemias in humans. MLL1 is a member of the SET1 family of histone H3 lysine 4 (H3K4) methyltransferases, which are required for transcription of genes involved in hematopoiesis and development. MLL1 associates with a sub-complex containing WDR5, RbBP5, Ash2L, and DPY-30 (WRAD), which …
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Exploring Histone Modifying Complexes with a Proteomic Approach
… der Rad6 Komplex aus S. pombe (Sp_Rad6C). Der Set1 Komplex (Set1C) beinhaltet 8 Bausteine, methylisiert Lysin 4 in Histon H3 und ist die erste, entdeckte Histone H3 Lysin 4 Methyltransferase. Es beinhaltet ein Ash2 Homolog (Bre2), einen bekannten Baustein von trxG. Kürzlich wurden Rad6 …
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Molecular and Genetic Analysis of the Role of Ku in Silencing and Telomere Function in Saccharomyces Cerevisiae
… roles in silencing (YKU70, SIR1, SAS2, SAS5, SET1, ASF1) and telomere length regulation (YKU70, BDF1, ANC1, RAD50, TEL1, RAD52). Double mutant analysis revealed functional relationships between genes by generating a network of 241 synthetic interactions between 144 genes at 30°C and a …
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Histone H3 K4 Methylation Regulates The Spindle Assembly Checkpoint Through Direct Binding of Multiple Checkpoint Components and Cdc20
… one full copy of the genome. Our data show <em>SET1 </em>mutants and histone H3K4 mutants display a resistance to the mitotic poison, benomyl. Moreover methylated histone H3 directly binds to Spindle Assembly Checkpoint proteins Bub3 and Mad2 as well as the activator of the Anaphase Promoting …
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WDR5 Network Analysis Using Ensemble Approaches
… These interacting partners include the SET1 family of proteins and retinoblastoma binding protein-5 (RbBP5). In this work we used multiple ensemble measurement based bulk-phase techniques to characterize WDR5's interactions. We utilized biolayer interferometry (BLI) and surface plasmon …
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Identification and Characterization of the Multifunctional Epigenetic Regulator CFP1 as an ERK1/2 Substrate
… is a vital component of the H3K4 trimethylating Set1A/B complexes to promote gene transcription. CFP1 has also been shown to interact physically and functionally with the major maintenance DNA methyltransferase DNMT1. We are interested in defining how substrate targeting of CFP1 by ERK1/2 …