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Showing 1 to 3 of 3 for “"SERINC3"”.
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Are bats evolving more potent antiviral immune systems? Investigating the evolution and antiviral capacity of SERINC3 in Rhinolophus bats
… these genes is the antiviral restriction factor SERINC3. The SERINC protein family is a collection of transmembrane proteins conserved amongst mammals. SERINC3 and SERINC5 are members of this family that have previously been shown to inhibit viral infectivity in multiple viruses such as …
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The cellular and molecular basis of the Nef requirement for HIV-1 infectivity
… protein SERINC5, and to a lesser extent SERINC3, as potent inhibitors of HIV-1 infectivity counteracted by the viral protein Nef [Rosa et al., 2015]. SERINC5 is predominantly localized on the plasma membrane where it is efficiently incorporated into budding HIV-1 virions and impairs …
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An investigation of the function of adaptor protein complex 4 (AP-4)
… transmembrane cargo proteins, ATG9A, SERINC1 and SERINC3, were found to be mislocalised in AP-4-deficient cells. Two novel cytosolic AP-4 accessory proteins, RUSC1 and RUSC2, were also identified. Further proteomic analyses confirmed the interactions between these proteins. AP-4 deficiency was …