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Showing 1 to 12 of 12 for “"SERCA2a"”.
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Multivariate analysis of transcriptional changes following restoration of SERCA2a levels in failing rat hearts
We have identified the genes responsible for SERCA2a-induced reversal of heart failure, the leading cause of morbidity and mortality in the United States and developed countries. We have previously shown that restoration of a key enzyme that controls intracellular Ca2+ handling, the Sarcoplasmic …
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The Role of Phospholamban Cysteines in the Activation of the Cardiac Sarcoplasmic Reticulum Ca2+ Pump by Nitroxyl (HNO)
… regulates the sarco(endo)plasmic Ca2+-ATPase (SERCA2a) within the cardiac sarcoplasmic reticulum (CSR). SERCA2a regulates intracellular Ca2+- handling and thus plays a critical role in initiating cardiac contraction and relaxation. It is believed that dysregulation of SERCA2a is a contributing …
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Entwicklung und Erprobung eines in-vitro-Modellsystems zur Untersuchung von lastabhängigen Regulationsvorgängen der myokardialen Genexpression
… von Vor- oder Nachlast auf die Expression von SERCA2a (Sarkoplasmatisches-Retikulum-Calcium-ATPase, Isoform 2A) in isolierten Kaninchen-Herzmuskelpräparaten zu untersuchen. Diese Untersuchungen könnten möglicherweise wichtige Hinweise auf die Regulationsmechanismen der SERCA2a-Expression bei …
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Age-associated changes to calcium handling proteins across the whole heart
… elucidating the age-associated reduced role of SERCA2a. The decline in protein expression of SERCA2a, RYR2 and Caᵥ1.2 supported dysfunctional spontaneous activity in the elderly SA node. In addition there was an age related increase in sensitivity to nifedipine which highlighted the importance …
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Investigating the protective role of the natural hormone Melatonin, in reducing drug-induced cardiotoxicity in the therapy of chronic diseases
… cardiac electrophysiology and arrhythmia (Scn5a, SERCA2a), calcium handling (SERCA2a) and cardiac remodelling (Myh7, ms1). Melatonin pre-treatment attenuated or completely blocked this DOX-induced alteration in gene expression in cardiomyocytes. In conclusion, the present result demonstrated for …
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To Phosphorylate or Not to Phosphorylate: The Role of Tropomyosin Phosphorylation in Cardiac Function and Disease
… animals. In TG hearts, there is an increase in SERCA2a expression and an increase in PLN phosphorylation at Ser16. This increase in energetic demand placed on the heart both by the increase in SERCA2a activity coupled with the increased energetic demand that occurs during the onset of cardiac …
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Efeitos da restrição protéica experimental sobre a morfologia do miocárdio e as propriedades mecânicas dos miócitos cardíacos isolados em ratos Fisher após o desmame
… o GRP apresentou menor expressão protéica de SERCA2a e menor transiente de cálcio em relação ao GC, provocando prejuízos na mecânica celular. De acordo com esses resultados, foi possível concluir que a restrição protéica severa altera não apenas a morfologia do coração, mas também aspectos …
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Molecular mapping of the rabbit atrioventricular node
… the Ca2+ handling proteins, RYR2, RYR3, NCXI and SERCA2a, there were no significant differences between tissues. In situ hybridisation staining revealed further complexity of the AVN conduction axis tissue. A region of loosely packed atrial tissue immediately adjacent to the nodal tissue was …
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Nesfatin-1 Regulation of Cardiovascular Functions in Zebrafish and HL-1 Cardiomyocytes
… Atp2a2a mRNA encoding the calcium-handling pump, SERCA2a, while it has no effects on the expression of calcium handling protein RyR1b encoding mRNA. NUCB2 mRNA and NUCB2/nesfatin-1 like immunoreactivity was detected in the cytoplasm of mouse HL-1 cardiomyocytes. High glucose increased NUCB2 mRNA …
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Veränderungen der Calcium-Homöostase als mögliche Ursache einer linksventrikulären Funktionsstörung im humanen "hibernating myocardium"
… wie z.B. die sarkoplasmatische Calcium-ATPase (SERCA2a), Phospholamban (PLN), Natrium-Calcium Austauscher (NCX) und Ryanodin-Rezeptor (RyR2) waren daher Gegenstand der Untersuchungen und sollten im Einzelnen quantifiziert werden. Zusätzlich wurde das Hitzeschockprotein hsp70 untersucht, welches …
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Physical Mechanisms of Ca-ATPase Regulation in the Heart
The Ca-ATPase is an integral membrane enzyme which translocates two calcium ions from the cytoplasm of the cell to the sarcoplasmic reticulum lumen utilizing ATP breakdown as its energy source, in order to promote muscle relaxation. The focus of this research is the cardiac isoform of the Ca-ATPase …
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Functional, Structural and Molecular Alterations in the Heart and Kidney During Diabetes Mellitus
… cardiac sarcoplasmic reticulum Ca2+ATPase 2a (SERCA2a), ryanodine receptor (RyR2), Na2+/Ca2+ exchanger, phospholamban (Plb), L-type Ca2+ channel proteins (Cav1.2 and Cav1.3), calmodulin2 (Calm2) and Ca2+/calmodulin-dependant protein kinase II delta (CaMK2d) were significantly (p<0.05) altered …