Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 4 of 4 for “"SEL1L"”.
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ESPRESSIONE DI SEL1L NEL CARCINOMA MAMMARIO - CORRELAZIONI CLINICO PATOLOGICHE
… senescence or permanent arrest of cell division. SEL1L is a member of endoplasmic-reticulum (ER)-associated protein degradation (ERAD)-specific ubiquitin ligase complex that functions in the detection, targeting, and degradation of malfolded and normal endoplasmic reticulum (ER) resident proteins …
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Aberrations of A Putative Tumor Suppressor Gene Sel1L In Pancreatic Ductal Adenocarcinoma
… in the United States. <em>Sel-1-like </em>(<em>SEL1L</em>) is a putative tumor suppressor gene that is downregulated in a significant proportion of human pancreatic ductal adenocarcinoma (PDAC). It was hypothesized that <em>SEL1L</em> expression could be down-modulated by somatic mutation, loss …
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The Genetic Basis Of Neurodegenerative Diseases: The Role Of Sel1L In Tau Pathology And Neuropathology
… The gene Suppressor enhancer lin-12 1-Like (SEL1L) is widely known to encode an endoplasmic reticulum (ER) membrane protein and is highly expressed in CNS neurons. To investigate the potential association between neurodegeneration and dysfunction of SEL1L, we generated and characterized mice …
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Using VHHs to study the function and control of the E2 Ubiquitin-conjugating enzyme UBC6e
… distinct from the conventional ERAD by Hrdl/SEL1L complex. To better understand how UBC6e is controlled, we developed VHH05, which associates with UBC6e with a low nanomolar dissociation constant. VHH05 enhances enzymatic activity of UBC6e by binding to a gateway helix on UBC6e (168-186). As …