Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 26 for “"SDF-1"”.
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Mechanisms of Mouse Primordial Germ Cell Migration: The Role of SDF-1 and Cytoskeletal Dynamics
… the role of stromal cell-derived factor-1 (SDF-1) in regulating PGCLC behaviour. We examined the role of stromal cell-derived factor-1 (SDF-1) in regulating PGCLC behaviour. SDF-1 is expressed along the migratory route of PGCs in vivo, and has previously been proposed to have a role in the …
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The effect of Stromal cell Derived Factor-1 (SDF-1) and collagen-GAG (Glycosaminoglycan) scaffold on skin wound healing
… chemokine, Stromal cell Derived Factor-1 (SDF-1) was incorporated into a highly porous collagen-glycosamino-glycan (GAG) matrix (skin substitute). The hypothesis is that this enhanced skin substitute would expedite wound healing and decrease abnormal scarring by a mechanism where stem cells …
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Die Bedeutung der Interaktion des Chemokins SDF-1 (CXCL12) mit CXCR4-Chemokinrezeptoren auf Leukämiezellen von Patienten mit Akuter Myeloischer Leukämie
KM - Stromazellen regulieren die Entwicklung und Proliferation HSC innerhalb des KM - Mikromilieus. Die AML stellt eine Neoplasie unreifer hämatopoetischer Zellen dar, durch die Verdrängung der gesunden Hämatopoese durch Blasten sind Teile des klinischen Erscheinungsbilds <br> der Erkrankung zu …
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Chemotactic behavior of immature and mature blood cells in response to the cytokines: SDF-1, steel factor, CKbeta-11 and SLC
This document only includes an excerpt of the corresponding thesis or dissertation. To request a digital scan of the full text, please contact the Ruth Lilly Medical Library's Interlibrary Loan Department (rlmlill@iu.edu).
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THE ROLE OF SDF-1[alpha] AS A VASCULOGENIC CHEMOKINE AND ENDOTHELIUM-ASSOCIATED CELL ADHESION MOLECULE FOR THE RECRUITMENT OF BONE MARROW-DERIVED PROGENITOR CELLS TO DEVELOPING TUMORS
… cancer therapy. Stromal-derived factor-1 alpha (SDF-1 alpha or CXCL12) is a chemoattractant for lymphocytes, hematopoietic progenitor cells, and vascular endothelial cells. SDF-1 alpha binds to the CXCR4 receptor on cell surfaces and to heparan sulfate in cell membranes and the extracellular …
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Untersuchungen zur Signaltransduktion des CXCR4 (CD 184) Chemokinrezeptors im Hinblick auf Vitalität und Migration humaner B-CLL-Zellen
… den CXCR4-Rezeptor (CD184) für das Chemokin SDF-1. Dieser Chemokinrezeptor spielt eine Schlüsselrolle für das Homing ins Knochenmark und die Stroma-vermittelte Apoptose-Resistenz. Stromazellen des Knochenmarks und Ammenzellen („nurse-like cells“, NLC) sezernieren konstitutiv SDF-1(CXCL 12). …
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Injectable chemokine-releasing gelatin matrices for enhancing endogenous regenerative responses in the injured rat brain
… such as the stromal cell-derived factor-I a (SDF-1 [alpha])/CXCR4 pathway and offer the potential to replace lost neurovascular elements. Endogenous regenerative responses are, however, not fully effective in the injured brain. Two prominent barriers are the loss of chemokine expression and …
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The Role of miR-126/126* in Microenvironmental Regulation of Cancer Metastasis
… of stromal cell-derived factor-1 alpha (Sdf-1α, also known as Cxcl12), and indirectly suppress the expression of chemokine (C-C motif) ligand 2 (Ccl2) by the cancer cells within the tumour mass in an Sdf-1α-dependent manner. In addition, in contrast with the majority of reports which have …
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The Effects of Chronic Cadmium Exposure on Breast Cancer Progression
… cadmium were shown to express higher levels of SDF-1— a chemokine known to contribute to cancer cell growth, migration and invasion. Results from this study demonstrated</p> <p>vithat the expression of SDF-1 was not only dependent on ER but also on c-jun and c-fos, and the interactions between …
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Chemotaxis of Central Nervous System-derived Tumor Cells within Controlled Microenvironments
… and the stromal cell-derived factors 1-alpha (SDF-1). Experiments utilized transwell assays and immunocytochemistry to identify receptor activation in MB migration, and used a microfluidic platform to examine directionality, trajectory, and gradient- dependence of motile cells. Data illustrates …
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The regulation of CXCR4 and CCR5 expression on human monocytes by Th1 and Th2 cytokines: Functional implications on cell migration and HIV infection.
… to migrate in response to the CXCR4 ligand SDF-1, and the CCR5 ligand MIP-1alpha, were measured. The consequences of decreases in CXCR4 and CCR5 expression by Th1 and Th2 cytokines were also investigated with respect to HIV entry and replication. (Abstract shortened by UMI.)
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Crisplant defects quantification and reduction at an amazon.com distribution center
… that can also be implemented in other FCs (i.e. SDF 1, TUL 1) with similar operation as RNO 1.
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Effekt einer transendokardialen kathetergestützten Applikation von Stromal cell derived factor 1[alpha] auf die linksventrikuläre Funktion im Herzinfarktmodell im Schwein
… Catheter-based transendocardial injection of SDF-1alpha into the infarct and periinfarct myocardium was performed two weeks after myocardial infarction (n = 12). A control group underwent sham-intervention (n = 8). Two and seven weeks after myocardial infarction electromechanical mapping (EMM) …
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Expression and function of the αVβ5 integrin during human B lymphopoiesis
… proliferation was enhanced by the chemokine SDF-1 and PDGF but not by the cytokines IL-3, IL-4, IL-7 or IL-11. This effect was apparently restricted to earlier B cell precursors and was independent of levels of expression of both αVβ5 and CXCR4. Stimulation of SMS-SB cells by αVβ5 ligands …
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Biomechanical And Biological Evaluation Of A Model Of Post-Traumatic Osteoarthritis Following Noninvasive, Traumatic Rupture Of The Anterior Cruciate Ligament
… (MSCs) and elevated stromal-cell derived factor (SDF-1) concentrations in the joint acutely. Biomarkers of cartilage breakdown and metabolism are elevated only slightly immediately after injury. In conclusion, while some studies may benefit from the more rapid onset of PTOA in the surgical ACL …
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Role of Bruton’s Tyrosine Kinase and Interleukin-6 in Plasma Cell Accumulation and Autoantibody Production in Lyn-Deficient Mice, A Model of Lupus
… migration of lyn-/- plasma cells towards SDF-1 and involves a B cell intrinsic effect of Lyn-deficiency. The second checkpoint regulates the class-switching of B cells with lupus-associated autoantigen specificities and the production of pathogenic autoantibodies. This step requires IL-6, …
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Turning Round: Optimizing the Anti-Inflammatory Properties of Equine Bone Marrow Derived Mesenchymal Stem Cells for Osteoarthritis Through Three-Dimensional Culture
… of IL-6 and PGE2, and gene expression of SDF-1 and TSG-6. IFN𝛾 and TNFα were not produced by eBMSC spheroids and IL-10 production varied between individuals. Spheroids maintain higher viability and lower senescence than monolayer eBMSCs after injection through a needle and form in …
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Chemokinaktivität induziert durch Interleukin-6
… adhere to endothelial cells as efficient as SDF-1-treated cells. For subsequent cell migration actin polymerization at the leading edge is important. Indeed, stimulation with IL-6 induces the actin polymerization in both, TUR-monocytic cells and RAW 264.7 macrophages as well as in primary …
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Stat3 Controls The Neutrophil Migratory Response to Cxcr2 and Its Ligand Mip-2 (Cxcl2)
… neutrophil mobilization, in contrast to SDF-1 (Cxcl12), which contributes to neutrophil retention in the bone marrow, requiring downregulation to promote neutrophil release. Using a murine model with conditional STAT3 deletion in bone marrow, we demonstrate that STAT3 regulates …
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