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Showing 1 to 4 of 4 for “"SCNAs"”.
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Probabilistic modelling of somatic alterations in bulk tissue and single cells using repeat DNA
… alterations are somatic copy number alterations (SCNAs). SCNAs have been shown to be major drivers of oncogenesis and are associated with prognosis and response to therapies. Current sequencing and array-based methods that are used to infer SCNAs are cost-prohibitive for widespread clinical use. A …
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Non-Invasive cancer detection: computational applications in liquid biopsy and radiomics
… the analysis of somatic copy number alterations (SCNAs). The panel's unique combination of elements, including genome-wide and focal single nucleotide polymorphisms (SNPs), exonic regions of key cancer-related genes, and a bespoke computational strategy, enhances the detection and quantification …
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Algorithms for analyzing complex structural variations in cancer genomes
… (INDELs), or somatic copy number alterations (SCNAs). Recently, there is a paradigm shift in the cancer genome study that more efforts have been devoted to characterizing large scale structural variations (SVs) in various cancer genomes. However, there are still pressing needs for designing …
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Haplotype-Informed Allelic Imbalance Detection From Rna In Cancer
… of somatic chromosomal copy number alterations (SCNAs), which result in allelic imbalance, i.e., deviations from the expected 1-to-1 allelic ratios at heterozygous loci. We initially applied a native version of our method to 1,970 tumor samples from 7 sites in The Cancer Genome Atlas (TCGA), …