Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 41 for “"SCLC"”.
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CRISPR-mediated interrogation of small cell lung cancer
Small cell lung cancer (SCLC) is a highly aggressive neuroendocrine lung carcinoma that remains among the most lethal of solid tumor malignancies. Despite decades of research, treatment outcomes for SCLC remain very poor, highlighting the need for novel approaches to target the disease. Recent …
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Histone Lysine Demethylase KDM4A as a Therapeutic Target for Small Cell Lung Cancer
Small cell lung cancer (SCLC) arises from neuroendocrine cells within the lung. Along with deletion or loss-of-function RB1 and TP53 mutations, which occur in almost all cases, subsets of SCLC are driven by specific lineage transcription factors including ASCL1, NEUROD1, POU2F3, or YAP1. The …
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Investigating the initiation and progression of small cell lung cancer
Small cell lung cancer (SCLC) comprises 18% of all lung cancer cases and is an aggressive disease with a five-year survival rate of less than 5%, mainly due to the advanced nature of the disease at the time of diagnosis. Despite the need to better understand this disease, the genetic lesions that …
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Hypoxic Adaptation and Arsenic Trioxide Treatment in Small Cell Lung Carcinoma
Small cell lung carcinoma (SCLC) is a very aggressive solid tumor and is often widely metastasized by the time of diagnosis. Despite good response to the initial chemotherapy, SCLC cells often develop multidrug resistance to conventionally used chemotherapeutic drugs, which cause almost all SCLC …
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ELUCIDATING THE MOLECULAR DETERMINANTS OF P53-MEDIATED PLEIOTROPIC EFFECTS IN SMALL CELL LUNG CANCER
Small cell lung cancer (SCLC) is the most lethal subtype of lung cancer and comprises ~15% of all lung cancer cases. Together with the retinoblastoma (Rb) tumor suppressor, p53 is inactivated in the vast majority (>90%) of SCLC cases. p53 is a pleiotropic tumor suppressor gene that responds to a …
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Development of Specific Inhibitors that Prevent hnRNPA1-Mediated Therapy Resistance in Small Cell Lung Cancer.
… abnormally expressed in Small cell lung cancer (SCLC); reducing hnRNP A1 in lung cancer cells inhibited cell growth and number of colonies, as well as arresting cells in the G0/G1 phase of the cell cycle. SCLC is extremely metastatic and aggressive; it is responsible for 13% of all lung cancer …
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Expression of Excision Repair Cross-Complementation Group 1 Protein Predicts Poor Outcome in Patients with Small Cell Lung Cancer
… of treatment failure in small cell lung cancer (SCLC). PATIENTS AND METHODS: Pretreatment tumor biopsy specimens from 77 patients with SCLC (limited stage: 40, extensive stage: 37) were analyzed for p53, bcl-2, bax and ERCC1 expression by immunohistochemistry. All patients were treated with …
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Epigenetic Therapy of Lung Cancers: Anti-tumoral effect of valproate on small cell lung cancer
… the outcome of small cell lung carcinoma (SCLC) patients is the poorest of any histological subtype with five-year survival rate of less than 20 and 5 % for limited and extensive stage respectively. Based on increasing evidence that inhibitors of histones deacetylases (HDAC) have anticancer …
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Analysis of ASCL1 in Neuroendocrine Lung Cancer
Small cell lung cancer (SCLC) is an understudied tumor subset with aggressive neuroendocrine carcinoma features. Previous studies have determined that the basic helix-loop-helix (bHLH) transcription factor achaete-scute homolog 1 (ASCL1) is essential for the survival and progression of many …
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The Hu Syndrome: At the Intersection of Cancer and Autoimmunity
… affects patients with small cell lung cancer (SCLC). Hu patients are diagnosed by the presence of antibodies in the blood that recognize the HuD antigen. HuD is normally restricted in expression to neurons of both the peripheral and central nervous systems, but ectopically expressed by SCLCs. …
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Glutamine Antagonism and Its Utlity [sic] as a Therapeutic Modality in Cancer
… these drugs. Relapsed small-cell lung cancer (SCLC) is characterized by an upregulation of de novo purine biosynthesis and have few durable therapies. Using metabolic tracing and untargeted metabolomics, I found that DON can inhibit purine metabolism in treatment-naïve and chemoresistant pairs …
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Fight the Power: Protest, Showdown and Civil Rights Activity in Three Southern Cities, 1960-1965.
… the South. Stumbling into a campaign in Albany, SCLC found thr right method in the use of nonviolent direct action. While Albany was a failure, it was this campaign that led to the campaigns of Birmingham and Selma which led in passage of the Civil Rights Act of 1964 and the Voting Rights Act of …
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Role of P300 Zz Domain In Chromatin Association and Histone Acetylation
… p300 is overexpressed in small cell lung cancer (SCLC), the most aggressive subtype of lung cancer. By CRISPR/Cas9-mediated gene manipulation, we found that p300 depletion impedes proliferation of human and mouse SCLC cells whereas CBP depletion has little or no effect. Depletion of p300 reduces …
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Educating for freedom: the Highlander Folk School in the Civil Rights Movement, 1954 to 1964
… of Tennessee closed Highlander Folk School, the SCLC adopted the Citizenship Education Program as its own. Under the auspices of the SCLC, Clark’s program became the paradigm for citizenship education throughout the Civil Rights Movement, up to and including the Freedom Schools incorporated into …
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Understanding and Targeting the FGF-2/S6K2 Signal Pathway in Small Cell Lung Cancer Towards the Development of Novel Anti-Cancer Treatments.
Small Cell Lung Cancer (SCLC) cells activate a signal pathway in response to chemotherapy, as a result the cancer rapidly develops chemoresistance. Since the late 1980’s SCLC has a poor prognosis with a 5 year survival rate of only 5%, highlighting the need for novel therapeutic intervention. This …
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Preparation and Characterization of Ferroelectric Thin Films for Tunable and Pyroelectric Applications
… shows bulk-limited space-charge-limited-current (SCLC) behavior at positive bias while interface-limited Fowler-Nordheim (FN) tunneling at negative bias. For the Pt/BTS/Pt structure, the dominant conduction mechanism is mainly controlled by the bulk-limited SCLC and/or Poole-Frenkel (PF) emission. …
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Amorphous hydrogenated boron carbide for solid-state direct-conversion thermal neutron detection
… we have used space-charge-limited current (SCLC) analysis to extract the charge carrier mobility in a-BC:H thin films. To better describe the extracted charge carrier mobility, we have presented an extension of SCLC theory to include negative field-dependence in mobility as well as a theory …
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Genome-Wide Analysis of Transcription Factors Ascl1 and Ptf1a in Development and Cancer
… growth in malignant small cell lung carcinoma (SCLC). It is unknown if Ascl1 and Ptf1a directly regulate different genes programs in these disparate tissues. Furthermore, Ptf1a and Ascl1 are members of same transcription factor family, which recognize and bind a similar DNA sequence. How these …
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D2R Dopamine Receptor Mediates Changes in Dual Specificity Phosphatase Expression in a Small Cell Lung Cancer Cell Line
… in DMS 53 cell line, a Small Cell Lung Cancer (SCLC). In this thesis, we have shown that treatment with NPA (N‑propylnorapomorphine), a dopamine receptor agonist inhibits ERK phosphorylation and proliferation in DMS 53 cells. NPA treatment causes significant increases in DUSP‑1 (MKP‑1), DUSP‑4 …
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Grassroots Impacts on the Civil Rights Movement: Christian Women Leaders’ Contributions to the Paradigm Shift in the Tactics of the Southern Christian Leadership Conference and Its Affiliates
… help major civil rights organizations, such as SCLC, SNCC, CORE, COFO, and the NAACP, work closely with local black people in the South who struggled with their underprivileged circumstances. This project investigates the key role of the grassroots leadership of Christian women leaders, which …
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