Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 41 for “"SCID-mice"”.
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Retinoic Acid Pathway Inhibition to Expand Human Hematopoietic Progenitor Cells with Islet Regenerative Capacity
… into streptozotocin (STZ)-treated NOD/SCID mice. However, UCB-derived ALDHhi cells are rare and expansion without the loss of regenerative function is required. We hypothesized that BMS 493, an inverse retinoic acid receptor agonist, will prevent HSPC differentiation of HSPC during …
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Development of a Human Immune System from Hematopoietic Stem Cells in a Human/Mouse Xenogeneic Model
… of severe combined immunodeficient (SCID) mice with human hematopoietic stem cells results in long-term engraftment and systemic reconstitution with human progenitor, B and myeloid cells but curiously, human T cells are rarely present in any tissue. While the implantation of SCID mice …
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Chimeric ANTI-CD19 Monoclonal Antibodies for the Treatment of Precursor B Cell Acute Lymphoblastic Leukemia
… anti-human CD19 MAb, HD37, has efficacy in SCID mice with human B cell tumors. Furthermore, homodimers consisting of two conjugated IgG molecules of HD37 are more effective than monomers at inducing tumor cell death. Yet, their large size prevents effective tumor penetration, and normal Fc …
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Inhibition of Mitochondrial Translation as a Therapeutic Strategy for Acute Myeloid Leukemia
… was assayed by human AML engraftment in NOD/SCID mice. Results: TIG induced cell death in primary AML patient samples (LD50, 3-6μM n=14), preferentially over normal hematopoietic cells. Likewise, in colony assays, TIG (5μM) reduced the clonogenic growth of AML samples (n=7) by 93%, …
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Role of the macrophage in acute kidney injury
… if delivered 24h prior to IRI. Immunodeficient SCID mice exhibited a protected injury phenotype after IRI, however derived no additional protection from the administration of either liposomal clodronate or i.v. apoptotic cells. These findings suggest that the protective phenotype must involve …
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Tracing of Alpha-to-Beta Cell Transition Following Treatment with CHIR-Injected Human Multipotent Stromal Cell Secreted Proteins
… recovery in streptozotocin (STZ) treated NOD/SCID mice. Here, we investigated whether this regeneration process involves alpha-to-beta cell conversion, using a Glucagon-iCre;Rosa26-TdTomato (GcgxTdT) lineage-tracing model. Following STZ-induced hyperglycemia induction and intrapancreatic CM …
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A TISSUE ENGINEERING APPROACH TO THE DEVELOPMENT OF AN IN VITRO 3D TUMOR MODEL FOR DRUG DELIVERY STUDIES
… closely approximate the subcutaneous tumors in SCID mice.
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Stimulations and modulations of chondrogenic differentiation of human embryonic stem cells
… pretreatment were implanted ectopically in SCID mice, TGFI?1-pretreated cells demonstrated maximum cartilage formation. Conversely, BMP2-pretreated cells showed minimum cartilage formation, possibly due to predominating osteogenic differentiation of hEB-derived cells.
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Frequency domain fluorescent molecular tomography and molecular probes for small animal imaging
… in severely compromised immunodeficient (SCID) mice bearing xenografted PC-3 prostate and T47-D breast cancer lesions demonstrated the ability of this new molecular probes to specifically target tumor tissue with a high selectively and affinity.
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Germline HOXB13 G84E Mutation Inhibits MEIS1-HOXB13 Driven Tumor Suppression in Prostate Cancer
… and progression of 22Rv1 tumor xenografts in SCID mice and were confirmed to have a significant reduction in the proteoglycans, Decorin and Lumican. Exogenous addition of Decorin and Lumican reduced growth and migration of PrCa cell lines. These data support the HOXB13-MEIS1 axis in PrCa while …
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Therapeutic Gene Delivery to Human Pancreatic Islets for Treatment of Diabetes and the Effect of TFO on Liver Fibrosis Induced by Bile Duct Ligation
… under the kidney capsules of diabetic NOD‑SCID mice reduced the blood glucose levels, and increased serum insulin and c‑peptide levels. Immunohistochemical staining of the islet bearing kidney sections at day 30 after transplantation was positive for human insulin, hVEGF and von Willebrand …
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Characterisation of open reading frames m29 and m29.1 in murine cytomegalovirus
… in immunocompetent BALB/c and immunodeficient SCID mice. Both mutants produced their expected transcripts but Rc29.1 virus produced no corresponding protein as examined by western blot using an antibody produced in rabbits to bacterially expressed protein. Failure to express the m29 ORF in …
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Epigenetic Therapy of Lung Cancers: Anti-tumoral effect of valproate on small cell lung cancer
… preclinical models of SCLC cells engrafted into SCID mice. The second line combination is presently tested in a clinical trial with patients presenting with refractory or relapsing small cell lung cancer (protocol 01081 at http://www.elcwp.org).
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A mouse model for studying gastrointestinal microbial ecology
… mouse model consisting of immunodeficient C.B-17 SCID mice colonized with the eight bacterial strains of the altered Schaedler flora (ASF). Specific and sensitive molecular methods were developed to accurately estimate the levels of different ASF strains. Distribution of specific ASF strains along …
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Engineering functional blood vessels in vivo
… derived endothelial cells were implanted into SCID mice, they formed blood vessels that integrated into the host circulatory system and served as blood conduits. Second, we compared the formation and function of engineered blood vessels generated from circulating endothelial progenitor cells …
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Nuclear magnetic resonance microscopy and diffusion
… vivo. NMR Microscopy of pancreatic islet of NOD-SCID mice in vitro has shown the feasibility of tracking T-lymphocytes infiltration into islets before the onset of any diabetes symptoms using contrast agents CLIO-Tat. Application of this to in vivo study will not only advance our understanding of …
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The Role of Prolactin in the Cellular Response to DNA Damaging Agents
… of doxorubicin induced DNA damaged cells in SCID mice compared to untreated or prolactin or doxorubicin alone. We hypothesize that this is in part due to the cross-talk of the prolactin and DNA damage response pathways that may be affecting the tumor microenvironment.
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Virulence and pathogenic mechanisms of <i>Legionella pneumophila</i>
… of severe combined immune deficient (SeID) mice. SCID mice did not become ill when given a potentially lethal aerosol of <i>L.pneumophila</i> and alveolar macrophages of these mice did not support the growth of <i>L.pneumophila in vitro</i>. SCID mice which had been reconstituted with human …
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Untersuchungen HLA-Klasse II-assoziierter, T-zellvermittelter Autoimmunität im humanisierten SCID-Mausmodell des Pemphigus vulgaris
… activation in an in vivo model. The humanized SCID mouse model allows the adoptive transfer of human peripheral blood lymphocytes (PBL) to establish a functional human immune system within the murine organism. PBL from a patient with active PV disease, from a HLA-homologous healthy control and …
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